About COVex

A Coronavirus Explorer


COVex (Coronavirus Explorer) is a unique online network and systems medicine platform for data analysis that integrates virus-human interactions for SARS-CoV-2 and SARS-CoV-1. It implements different network-based approaches for the identification of new drug targets and new repurposable drugs.

General workflow of the platform

  1. Select the viral interaction dataset (SARS-CoV1-Pfefferle, SARS-CoV1-VirHostNet, SARS-CoV2-Gordon).
  2. Select proteins of interest as seed proteins.
  3. Perform network analysis (multi-Steiner, TrustRank, KeyPathwayMiner, closeness centrality).
  4. Platform usage: basic and advanced options
  5. Inspect the resulting subnetworks.
  6. Find drugs associated with the subnetwork (TrustRank, closeness centrality).
  7. Download your results.

COVex also provides a quick analysis option to perform steps 3 to 5 (starting from the seed proteins) to return a list of drugs ranked by default using TrustRank.

Help/Contact information

  • Systems and Network Medicine: Sepideh Sadegh (sadegh@zw.tum.de)
  • Web platform: Julian Matschinske (julian.matschinske@wzw.tum.de)
  • Project coordination: Prof. Dr. Jan Baumbach (jan.baumbach@wzw.tum.de)
  • Lab Website: http://www.exbio.de

License

COVex is freely available for non-commercial use. The Software is provided "AS IS" without warranty whatsoever. COVex is publicly available and its source code is released under the GPLv3 license

Impressum

Prof. Dr. Jan Baumbach Chair of Experimental Bioinformatics
Phone: +49-8161-71-2136
Fax: +49-8161-71-2186
Email: exbio@wzw.tum.de
Address: ​​​Prof. Dr. Jan Baumbach
Chair of Experimental Bioinformatics
TUM School of Life Sciences Weihenstephan
Technical University of Munich
Maximus-von-Imhof-Forum 3
85354 Freising
Germany