About COVex

A Coronavirus Explorer


COVex (Coronavirus Explorer) is a unique online network and systems medicine platform for data analysis that integrates virus-human interactions for SARS-CoV-2 and SARS-CoV-1. It implements different network-based approaches for the identification of new drug targets and new repurposable drugs.

For detailed information please visit our blog: https://www.exbio.de/exbio-vs-covid-part-1/

General workflow of the platform

  1. Select the viral interaction dataset (SARS-CoV1-Pfefferle, SARS-CoV1-VirHostNet, SARS-CoV2-Gordon).
  2. Select proteins of interest as seed proteins.
  3. Perform network analysis (multi-Steiner, TrustRank, KeyPathwayMiner, closeness centrality).
  4. Platform usage: basic and advanced options
  5. Inspect the resulting subnetworks.
  6. Find drugs associated with the subnetwork (TrustRank, closeness centrality).
  7. Download your results.

COVex also provides a quick analysis option to perform steps 3 to 5 (starting from the seed proteins) to return a list of drugs ranked by default using TrustRank.

Help/Contact information

  • Systems and Network Medicine: Sepideh Sadegh (sadegh_AT_zw.tum.de)
  • Web platform: Julian Matschinske (julian.matschinske_AT_wzw.tum.de)
  • Project coordination: Prof. Dr. Jan Baumbach (jan.baumbach_AT_wzw.tum.de)
  • Lab Website: http://www.exbio.de


Impressum

Prof. Dr. Jan Baumbach Chair of Experimental Bioinformatics
Phone: +49-8161-71-2136
Fax: +49-8161-71-2186
Email: exbio_AT_wzw.tum.de
Address: ​​​Prof. Dr. Jan Baumbach
Chair of Experimental Bioinformatics
TUM School of Life Sciences Weihenstephan
Technical University of Munich
Maximus-von-Imhof-Forum 3
85354 Freising
Germany