diff --git a/src/app/components/analysis-panel/analysis-panel.component.ts b/src/app/components/analysis-panel/analysis-panel.component.ts
index ec0e09a761ceeab008045ce59e8b9707c1f9b8ed..a29f32c027a7a559b72fdbc1ab5a5ffa61c0f790 100644
--- a/src/app/components/analysis-panel/analysis-panel.component.ts
+++ b/src/app/components/analysis-panel/analysis-panel.component.ts
@@ -203,7 +203,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
// @ts-ignore
for (const g of Object.values(options.groups)) {
// @ts-ignore
- delete g.renderer
+ delete g.renderer;
}
this.drugstoneConfig.config.physicsOn = !isBig;
this.networkHandler.activeNetwork.networkInternal = new vis.Network(container, this.nodeData, options);
@@ -247,7 +247,8 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
if (nodeIds.length > 0) {
const nodeId = nodeIds[0];
const node = this.nodeData.nodes.get(nodeId);
- if (node.nodeType === 'drug' || node.drugstoneId === undefined || node.drugstoneType !== 'protein') {
+ if (node.drugstoneId === undefined || node.nodeType === 'drug' || node.drugstoneType !== 'protein') {
+ this.analysis.unmappedNodeToast();
return;
}
const wrapper = getWrapperFromNode(node);
@@ -294,7 +295,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
selected,
this.networkHandler.activeNetwork.getGradient(item.id),
this.networkHandler.activeNetwork.nodeRenderer
- )
+ );
updatedNodes.push(nodeStyled);
}
this.nodeData.nodes.update(updatedNodes);
@@ -317,8 +318,9 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
const updatedNodes = [];
this.nodeData.nodes.forEach((node) => {
const isSeed = this.networkHandler.activeNetwork.highlightSeeds ? this.networkHandler.activeNetwork.seedMap[node.id] : false;
- if (!isSeed)
- return
+ if (!isSeed) {
+ return;
+ }
const nodeStyled = NetworkSettings.getNodeStyle(
node,
this.myConfig,
@@ -371,8 +373,8 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
this.analysis.switchSelection('main');
this.token = null;
this.tokenChange.emit(this.token);
- this.legendService.remove_from_context('drug')
- this.legendService.remove_from_context('drugTarget')
+ this.legendService.remove_from_context('drug');
+ this.legendService.remove_from_context('drugTarget');
this.emitVisibleItems(false);
}
@@ -399,12 +401,14 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
if (normalize) {
normalizeFn(this.tableProteins);
- if (this.task.info.target === 'drug')
- normalizeFn(this.tableDrugs)
+ if (this.task.info.target === 'drug') {
+ normalizeFn(this.tableDrugs);
+ }
} else {
unnormalizeFn(this.tableProteins);
- if (this.task.info.target === 'drug')
- unnormalizeFn(this.tableDrugs)
+ if (this.task.info.target === 'drug') {
+ unnormalizeFn(this.tableDrugs);
+ }
}
}
@@ -434,20 +438,20 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
this.proteins = [];
this.effects = [];
const network = result.network;
- network.nodes = [...new Set<string>(network.nodes)]
+ network.nodes = [...new Set<string>(network.nodes)];
const details = attributes.details || {};
- const nodeIdMap = {}
+ const nodeIdMap = {};
// @ts-ignore
Object.entries(details).filter(e => e[1].drugstoneType === 'protein').forEach(e => {
// @ts-ignore
e[1].drugstoneId.forEach(id => {
- nodeIdMap[id] = e[1][identifier][0]
- })
- })
+ nodeIdMap[id] = e[1][identifier][0];
+ });
+ });
for (const nodeId of network.nodes) {
if (details[nodeId]) {
- const nodeDetails = details[nodeId]
+ const nodeDetails = details[nodeId];
nodeDetails.id = nodeDetails.id ? nodeDetails.id : (typeof nodeDetails.drugstoneId === 'string' ? nodeDetails.drugstoneId : nodeDetails.drugstoneId[0]);
if (nodeDetails.drugstoneId && nodeDetails.drugstoneType === 'protein') {
// node is protein from database, has been mapped on init to backend protein from backend
@@ -464,13 +468,13 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
} else {
// node is custom input from user, could not be mapped to backend protein
nodeDetails.group = nodeDetails.group ? nodeDetails.group : 'default';
- nodeDetails.label = nodeDetails.label ? nodeDetails.label : nodeDetails[identifier]
+ nodeDetails.label = nodeDetails.label ? nodeDetails.label : nodeDetails[identifier];
}
// further analysis and the button function can be used to highlight seeds
// option to use scores[node] as gradient, but sccores are very small
- nodes.push(NetworkSettings.getNodeStyle(nodeDetails as Node, config, false, false, 1, this.networkHandler.activeNetwork.nodeRenderer))
+ nodes.push(NetworkSettings.getNodeStyle(nodeDetails as Node, config, false, false, 1, this.networkHandler.activeNetwork.nodeRenderer));
} else {
- console.log("Missing details for " + nodeId)
+ console.log('Missing details for ' + nodeId);
}
}
@@ -478,10 +482,10 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
const uniqEdges = [];
for (const edge of network.edges) {
- const e = mapCustomEdge(edge, this.myConfig)
- e.from = e.from[0] === 'p' && nodeIdMap[e.from] ? nodeIdMap[e.from] : e.from
- e.to = e.to[0] === 'p' && nodeIdMap[e.to] ? nodeIdMap[e.to] : e.to
- const hash = e.from + "_" + e.to;
+ const e = mapCustomEdge(edge, this.myConfig);
+ e.from = e.from[0] === 'p' && nodeIdMap[e.from] ? nodeIdMap[e.from] : e.from;
+ e.to = e.to[0] === 'p' && nodeIdMap[e.to] ? nodeIdMap[e.to] : e.to;
+ const hash = e.from + '_' + e.to;
if (uniqEdges.indexOf(hash) === -1) {
uniqEdges.push(hash);
edges.push(e);
@@ -489,7 +493,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
}
// remove self-edges/loops
if (!config.selfReferences) {
- edges = edges.filter(el => el.from !== el.to)
+ edges = edges.filter(el => el.from !== el.to);
}
return {
nodes,
@@ -498,15 +502,17 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
}
getResultNodes() {
- if (this.nodeData && this.nodeData['nodes'])
- return this.nodeData['nodes'].get()
- return []
+ if (this.nodeData && this.nodeData['nodes']) {
+ return this.nodeData['nodes'].get();
+ }
+ return [];
}
getResultEdges() {
- if (this.nodeData && this.nodeData['edges'])
- return this.nodeData['edges'].get().filter(e => !e.id || !e.groupName || (typeof e.from === 'string' && typeof e.to === 'string'))
- return []
+ if (this.nodeData && this.nodeData['edges']) {
+ return this.nodeData['edges'].get().filter(e => !e.id || !e.groupName || (typeof e.from === 'string' && typeof e.to === 'string'));
+ }
+ return [];
}
public tableProteinSelection = (e): void => {
@@ -528,7 +534,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
}
this.analysis.addItems(addItems);
this.analysis.removeItems(removeItems);
- }
+ };
public toggleFullscreen() {
this.fullscreen = !this.fullscreen;
diff --git a/src/app/components/info-tile/info-tile.component.html b/src/app/components/info-tile/info-tile.component.html
index 2fbb52888e2b2d653c75dbaa1b0f66e12269e19c..72b4caa836fdabc15d5810b2f9495b78a7d401cb 100644
--- a/src/app/components/info-tile/info-tile.component.html
+++ b/src/app/components/info-tile/info-tile.component.html
@@ -132,11 +132,11 @@
</a>
</p>
<p
- *ngIf="wrapper.data.groupName"
+ *ngIf="drugstoneConfig.config.nodeGroups[networkHandler.activeNetwork.selectedWrapper.data[networkHandler.activeNetwork.selectedWrapper.data.group === 'selectedNode' ? '_group':'group']].groupName"
[ngClass]="{ 'text-normal': drugstoneConfig.smallStyle }"
>
<b><span>Group:</span></b>
- <span class="is-capitalized"> {{ wrapper.data.groupName }}</span>
+ <span class="is-capitalized"> {{drugstoneConfig.config.nodeGroups[networkHandler.activeNetwork.selectedWrapper.data[networkHandler.activeNetwork.selectedWrapper.data.group === 'selectedNode' ? '_group':'group']].groupName }}</span>
</p>
</div>
@@ -146,7 +146,7 @@
(valueChange)="
$event ? analysis.addItems([wrapper]) : analysis.removeItems([wrapper])
"
- textOn="Seed"
+ textOn="Selected"
textOff="Off"
tooltipOn="Add protein to selection."
tooltipOff="Remove protein from selection."
diff --git a/src/app/components/info-tile/info-tile.component.ts b/src/app/components/info-tile/info-tile.component.ts
index eca0380297456eea7622f525671cb0e6917adee5..9ae830a2ce50a4f61cca0a4940350b3c6e58f9d0 100644
--- a/src/app/components/info-tile/info-tile.component.ts
+++ b/src/app/components/info-tile/info-tile.component.ts
@@ -2,6 +2,7 @@ import {Component, Input, OnInit} from '@angular/core';
import {DrugstoneConfigService} from 'src/app/services/drugstone-config/drugstone-config.service';
import {Wrapper} from '../../interfaces';
import {AnalysisService} from '../../services/analysis/analysis.service';
+import {NetworkHandlerService} from '../../services/network-handler/network-handler.service';
@Component({
@@ -13,7 +14,7 @@ export class InfoTileComponent implements OnInit {
@Input() public wrapper: Wrapper;
@Input() public expressions: any;
- constructor(public drugstoneConfig: DrugstoneConfigService, public analysis: AnalysisService) {
+ constructor(public drugstoneConfig: DrugstoneConfigService, public analysis: AnalysisService, public networkHandler: NetworkHandlerService) {
}
diff --git a/src/app/components/network/network.component.ts b/src/app/components/network/network.component.ts
index 331fc3bb7e632d1dd2f44f5ef3ff343e78983a4a..643a00f5351fc77c9c4233cef98762e3b9d9de75 100644
--- a/src/app/components/network/network.component.ts
+++ b/src/app/components/network/network.component.ts
@@ -348,15 +348,26 @@ export class NetworkComponent implements OnInit {
this.nodeRenderer = null;
const updatedNodes = [];
// for (const item of this.proteins) {
- for (const node of this.nodeData.nodes.get().filter(n => n.drugstoneType === 'protein')) {
- if (node.drugstoneId === undefined) {
- // nodes that are not mapped to backend remain untouched
- continue;
- }
- // const node: Node = this.nodeData.nodes.get(item.id);
- if (!node) {
- continue;
- }
+ const proteins = this.nodeData.nodes.get().filter(n => n.drugstoneId && n.drugstoneType === 'protein')
+ for (const node of proteins) {
+ const pos = this.networkInternal.getPositions([node.id]);
+ node.x = pos[node.id].x;
+ node.y = pos[node.id].y;
+ Object.assign(
+ node,
+ NetworkSettings.getNodeStyle(
+ node,
+ this.drugstoneConfig.config,
+ node.isSeed && this.networkHandler.activeNetwork.highlightSeeds,
+ false,
+ 1.0,
+ this.nodeRenderer
+ )
+ );
+ updatedNodes.push(node);
+ }
+ this.nodeData.nodes.update(updatedNodes);
+ for (const node of proteins) {
const pos = this.networkInternal.getPositions([node.id]);
node.x = pos[node.id].x;
node.y = pos[node.id].y;
@@ -370,13 +381,13 @@ export class NetworkComponent implements OnInit {
1.0,
this.nodeRenderer
)
- )
+ );
updatedNodes.push(node);
}
this.nodeData.nodes.update(updatedNodes);
} else {
- this.selectedTissue = tissue
+ this.selectedTissue = tissue;
const minExp = 0.3;
// filter out non-proteins, e.g. drugs
const proteinNodes = [];
diff --git a/src/app/config.ts b/src/app/config.ts
index 437a268bdf4e0c70dc37045dbaaf7ce0a0a6b612..4d792077d0b6660b8516993c7f061fe0bf25817a 100644
--- a/src/app/config.ts
+++ b/src/app/config.ts
@@ -1,9 +1,9 @@
-import { AlgorithmTarget, AlgorithmType, QuickAlgorithmType } from './interfaces';
+import {AlgorithmTarget, AlgorithmType, QuickAlgorithmType} from './interfaces';
// https://visjs.github.io/vis-network/docs/network/nodes.html
export interface NodeGroup {
groupName?: string;
- groupID?:string;
+ groupID?: string;
color?: any;
shape?: 'circle' | 'triangle' | 'star' | 'square' | 'image' | 'text' | 'ellipse' | 'box' | 'diamond' | 'dot';
type?: string;
@@ -32,6 +32,7 @@ export type InteractionDrugProteinDB = 'NeDRex' | 'DrugBank' | 'DrugCentral' | '
export type InteractionProteinProteinDB = 'NeDRex' | 'BioGRID' | 'IID' | 'IntAct' | 'STRING' | 'APID';
export type IndicationDrugDisorderDB = 'NeDRex' | 'CTD' | 'DrugCentral' | 'DrugBank';
export type AssociatedProteinDisorderDB = 'NeDRex' | 'DisGeNET' | 'OMIM';
+export type AdvAnalysisContentTypes = 'drug-target-search' | 'drug-search' | 'enrichment-gprofiler';
// TODO: should this be external or integrated in the backend?
@@ -50,6 +51,7 @@ export interface IConfig {
showItemSelector: boolean;
showSimpleAnalysis: boolean;
showAdvAnalysis: boolean;
+ showAdvAnalysisContent: Array<AdvAnalysisContentTypes>;
showTasks: boolean;
showSelection: boolean;
showNetworkMenu: false | 'left' | 'right';
@@ -73,7 +75,7 @@ export interface IConfig {
nodeGroups: { [key: string]: NodeGroup };
edgeGroups: { [key: string]: EdgeGroup };
selfReferences: boolean;
- customEdges: {default: boolean, selectable: boolean};
+ customEdges: { default: boolean, selectable: boolean };
interactionDrugProtein: InteractionDrugProteinDB;
interactionProteinProtein: InteractionProteinProteinDB;
indicationDrugDisorder: IndicationDrugDisorderDB;
@@ -90,37 +92,37 @@ export interface IConfig {
const defaultNodeGroup: NodeGroup = {
- // this default group is used for default node group values
- // and is fallback in case user does not provide any nodeGroup
- groupName: 'Default Node Group',
- ctxRenderer: null,
- color: {
- border: '#FFFF00',
- background: '#FFFF00',
- highlight: {
- border: '#FF0000',
- background: '#FF0000'
- },
- },
- shape: 'triangle',
- type: 'default type',
- detailShowLabel: false,
- font: {
- color: '#000000',
- size: 14,
- face: 'arial',
- background: undefined,
- strokeWidth: 0,
- strokeColor: '#ffffff',
- align: 'center',
- bold: false,
- ital: false,
- boldital: false,
- mono: false,
- },
- borderWidth: 1,
- borderWidthSelected: 2
- };
+ // this default group is used for default node group values
+ // and is fallback in case user does not provide any nodeGroup
+ groupName: 'Default Node Group',
+ ctxRenderer: null,
+ color: {
+ border: '#FFFF00',
+ background: '#FFFF00',
+ highlight: {
+ border: '#FF0000',
+ background: '#FF0000'
+ },
+ },
+ shape: 'triangle',
+ type: 'default type',
+ detailShowLabel: false,
+ font: {
+ color: '#000000',
+ size: 14,
+ face: 'arial',
+ background: undefined,
+ strokeWidth: 0,
+ strokeColor: '#ffffff',
+ align: 'center',
+ bold: false,
+ ital: false,
+ boldital: false,
+ mono: false,
+ },
+ borderWidth: 1,
+ borderWidthSelected: 2
+};
const connectorNodeGroup: NodeGroup = JSON.parse(JSON.stringify(defaultNodeGroup));
connectorNodeGroup.groupName = 'Connector Nodes';
@@ -143,6 +145,7 @@ export const defaultConfig: IConfig = {
showItemSelector: true,
showSimpleAnalysis: true,
showAdvAnalysis: true,
+ showAdvAnalysisContent: ['drug-search', 'drug-target-search', 'enrichment-gprofiler'],
showSelection: true,
showTasks: true,
showNetworkMenu: 'right',
diff --git a/src/app/interfaces.ts b/src/app/interfaces.ts
index cf6f8832a480353c55b74aba5228ad8b164a68c0..68bda05b5470ad6df6c77983ced9b0647274464a 100644
--- a/src/app/interfaces.ts
+++ b/src/app/interfaces.ts
@@ -200,6 +200,7 @@ export interface Wrapper {
color?: string;
interactions?: any;
group?: string;
+ _group?: string;
groupName?: string;
proteinName?: Array<string>;
uniprotAc?: Array<string>;
diff --git a/src/app/network-settings.ts b/src/app/network-settings.ts
index 01d0b927b4fb78ce1583de2e9f11add359c1a6c3..a645b6d7adf64017104be5fbc23f37db1aa46059 100644
--- a/src/app/network-settings.ts
+++ b/src/app/network-settings.ts
@@ -103,36 +103,38 @@ export class NetworkSettings {
// use lodash merge to not lose deep attributes, e.g. "font.size"
// @ts-ignore
if (node._group)
+ {
// @ts-ignore
- node.group = node._group
+ node.group = node._group;
+ }
// @ts-ignore
if (node._shadow) { // @ts-ignore
- node.shadow = node._shadow
- }else{
+ node.shadow = node._shadow;
+ } else {
if (config.nodeGroups[node.group].shadow) {
- node.shadow = {enabled: config.nodeGroups[node.group].shadow}
- node.shadow.color = 'rgba(0,0,0,0.5)'
+ node.shadow = {enabled: config.nodeGroups[node.group].shadow};
+ node.shadow.color = 'rgba(0,0,0,0.5)';
} else {
- node.shadow = {color: 'rgba(0,0,0,0.5)'}
+ node.shadow = {color: 'rgba(0,0,0,0.5)'};
}
}
if (isSeed) {
// apply seed node style to node
// @ts-ignore
- node._group = node.group
- node.group = 'seedNode'
+ node._group = node.group;
+ node.group = 'seedNode';
}
// selection on purpose after seed style, so seed style will be combined with selection style
if (isSelected) {
// @ts-ignore
- node._group = node.group
+ node._group = node.group;
// apply selected node style to node
- node.group = 'selectedNode'
+ node.group = 'selectedNode';
if (config.nodeGroups[node.group].shadow) {
- node.shadow = {enabled: config.nodeGroups[node.group].shadow}
- node.shadow.color = '#000000'
+ node.shadow = {enabled: config.nodeGroups[node.group].shadow};
+ node.shadow.color = '#000000';
} else {
- node.shadow = {color: '#000000'}
+ node.shadow = {color: '#000000'};
}
}
@@ -145,26 +147,26 @@ export class NetworkSettings {
if (renderer !== null) {
// @ts-ignore
node.shape = 'custom';
- node.color = {opacity: gradient}
- node.opacity = gradient
+ node.color = {opacity: gradient};
+ node.opacity = gradient;
if (isSeed) {
// apply seed node style to node
// @ts-ignore
- node.color = config.nodeGroups[node.group].color
- }else{
- delete node.color
+ node.color = config.nodeGroups[node.group].color;
+ } else {
+ delete node.color;
}
// @ts-ignore
- node._shadow = node.shadow
+ node._shadow = node.shadow;
if (config.nodeGroups[node.group].shadow) {
- node.shadow = {enabled: config.nodeGroups[node.group].shadow}
- node.shadow.color = 'rgba(0,0,0,0.5)'
+ node.shadow = {enabled: config.nodeGroups[node.group].shadow};
+ node.shadow.color = 'rgba(0,0,0,0.5)';
} else {
- node.shadow = {color: 'rgba(0,0,0,0.5)'}
+ node.shadow = {color: 'rgba(0,0,0,0.5)'};
}
node.ctxRenderer = renderer;
} else {
- node.opacity = undefined
+ node.opacity = undefined;
delete node.ctxRenderer;
}
diff --git a/src/app/pages/explorer-page/explorer-page.component.html b/src/app/pages/explorer-page/explorer-page.component.html
index 9460ee255372bb9e4974e64d5b91b77e2c56d849..45d2120482c83f3f943be3c382220466e02f84c1 100644
--- a/src/app/pages/explorer-page/explorer-page.component.html
+++ b/src/app/pages/explorer-page/explorer-page.component.html
@@ -50,7 +50,7 @@
*ngIf="networkHandler.activeNetwork.selectedWrapper"
>
<span>
- {{ drugstoneConfig.config.nodeGroups[networkHandler.activeNetwork.selectedWrapper.data.group].groupName }}
+ {{ drugstoneConfig.config.nodeGroups[networkHandler.activeNetwork.selectedWrapper.data[networkHandler.activeNetwork.selectedWrapper.data.group === 'selectedNode' ? '_group':'group']].groupName}}
</span>
</ng-container>
</p>
@@ -123,9 +123,9 @@
<p class="heading">Nodes</p>
<p class="title">
{{
- networkHandler.activeNetwork.currentViewNodes != null
- ? networkHandler.activeNetwork.currentViewNodes.length
- : 0
+ networkHandler.activeNetwork.currentViewNodes != null
+ ? networkHandler.activeNetwork.currentViewNodes.length
+ : 0
}}
</p>
</div>
@@ -135,9 +135,9 @@
<p class="heading">Edges</p>
<p class="title">
{{
- networkHandler.activeNetwork.currentViewEdges != null
- ? networkHandler.activeNetwork.currentViewEdges.length
- : 0
+ networkHandler.activeNetwork.currentViewEdges != null
+ ? networkHandler.activeNetwork.currentViewEdges.length
+ : 0
}}
</p>
</div>
@@ -227,7 +227,8 @@
</header>
<div *ngIf="collapseAnalysis">
<div class="card-content">
- <div class="field">
+ <div class="field"
+ *ngIf="!drugstoneConfig.config.showAdvAnalysisContent || drugstoneConfig.config.showAdvAnalysisContent.includes('drug-search')">
<div
class="control"
pTooltip="Find drug targets for the selected proteins."
@@ -250,7 +251,7 @@
</button>
</div>
</div>
- <div class="field">
+ <div class="field" *ngIf="!drugstoneConfig.config.showAdvAnalysisContent || drugstoneConfig.config.showAdvAnalysisContent.includes('drug-target-search')">
<div
class="control"
pTooltip="Find drugs for the selected proteins."
@@ -267,14 +268,14 @@
[disabled]="analysis.getCount() === 0"
[ngClass]="{ 'text-small': drugstoneConfig.smallStyle }"
>
- <app-fa-solid-icon icon="capsules" classString="first-item-in-button"></app-fa-solid-icon>
+ <app-fa-solid-icon icon="capsules" classString="first-item-in-button"></app-fa-solid-icon>
<span>
{{ drugstoneConfig.config.taskDrugName }}
</span>
</button>
</div>
</div>
- <div class="field">
+ <div class="field" *ngIf="!drugstoneConfig.config.showAdvAnalysisContent || drugstoneConfig.config.showAdvAnalysisContent.includes('enrichment-gprofiler')">
<div class="control">
<a
*ngIf="analysis.getCount() > 0"
@@ -414,53 +415,53 @@
*ngIf="analysis.getCount() > 0"
>
<thead>
- <tr>
- <td>Label</td>
- <td>Group</td>
- <td *ngIf="drugstoneConfig.config.identifier !== 'symbol'">
- Symbol
- </td>
- <td *ngIf="drugstoneConfig.config.identifier !== 'uniprot'">
- Uniprot
- </td>
- <td>Actions</td>
- </tr>
+ <tr>
+ <td>Label</td>
+ <td>Group</td>
+ <td *ngIf="drugstoneConfig.config.identifier !== 'symbol'">
+ Symbol
+ </td>
+ <td *ngIf="drugstoneConfig.config.identifier !== 'uniprot'">
+ Uniprot
+ </td>
+ <td>Actions</td>
+ </tr>
</thead>
<tbody>
- <tr *ngFor="let p of analysis.getSelection()">
- <td>
- <p class="is-capitalized">{{ p.data.label }}</p>
- </td>
- <td>
- <p>
- {{
- drugstoneConfig.config.nodeGroups[p.data['_group']][
- "groupName"
- ]
- }}
- </p>
- </td>
- <td *ngIf="drugstoneConfig.config.identifier !== 'symbol'">
- <p>{{ p.data.symbol }}</p>
- </td>
- <td
- *ngIf="drugstoneConfig.config.identifier !== 'uniprot'"
- class="uniprot"
- title="{{ p.data.uniprotAc }}"
+ <tr *ngFor="let p of analysis.getSelection()">
+ <td>
+ <p class="is-capitalized">{{ p.data.label }}</p>
+ </td>
+ <td>
+ <p>
+ {{
+ drugstoneConfig.config.nodeGroups[p.data['_group']][
+ "groupName"
+ ]
+ }}
+ </p>
+ </td>
+ <td *ngIf="drugstoneConfig.config.identifier !== 'symbol'">
+ <p>{{ p.data.symbol }}</p>
+ </td>
+ <td
+ *ngIf="drugstoneConfig.config.identifier !== 'uniprot'"
+ class="uniprot"
+ title="{{ p.data.uniprotAc }}"
+ >
+ <p>{{ p.data.uniprotAc }}</p>
+ </td>
+ <td>
+ <button
+ (click)="analysis.removeItems([p])"
+ class="button is-small is-danger is-outlined has-tooltip"
+ tooltipPosition="top"
+ pTooltip="Remove from selection."
>
- <p>{{ p.data.uniprotAc }}</p>
- </td>
- <td>
- <button
- (click)="analysis.removeItems([p])"
- class="button is-small is-danger is-outlined has-tooltip"
- tooltipPosition="top"
- pTooltip="Remove from selection."
- >
- <app-fa-solid-icon icon="trash"></app-fa-solid-icon>
- </button>
- </td>
- </tr>
+ <app-fa-solid-icon icon="trash"></app-fa-solid-icon>
+ </button>
+ </td>
+ </tr>
</tbody>
</table>
<i *ngIf="analysis.getCount() === 0">
diff --git a/src/app/pages/explorer-page/explorer-page.component.ts b/src/app/pages/explorer-page/explorer-page.component.ts
index 05da418ca7e63014c7d5ab11a197b4c11ab55022..2292ba0017fa364aec1794b31dc612f1d73f9990 100644
--- a/src/app/pages/explorer-page/explorer-page.component.ts
+++ b/src/app/pages/explorer-page/explorer-page.component.ts
@@ -309,7 +309,7 @@ export class ExplorerPageComponent implements OnInit, AfterViewInit {
if (!this.drugstoneConfig.config.showSidebar) {
// skip network options for selecting nodes when there are no options to use it
- return
+ return;
}
this.networkHandler.activeNetwork.networkInternal.on('doubleClick', (properties) => {
@@ -318,6 +318,7 @@ export class ExplorerPageComponent implements OnInit, AfterViewInit {
const nodeId = nodeIds[0];
const node = this.nodeData.nodes.get(nodeId);
if (node.drugstoneId === undefined || node.drugstoneType !== 'protein') {
+ this.analysis.unmappedNodeToast();
// skip if node is not a protein mapped to backend
return;
}
diff --git a/src/app/services/analysis/analysis.service.ts b/src/app/services/analysis/analysis.service.ts
index 54731865e1ffaab61049983cb8fb4e34cde68af7..83d5e71c48b801c208b9a14e47242503f31df03b 100644
--- a/src/app/services/analysis/analysis.service.ts
+++ b/src/app/services/analysis/analysis.service.ts
@@ -4,10 +4,10 @@ import {HttpClient} from '@angular/common/http';
import {environment} from '../../../environments/environment';
import {Injectable} from '@angular/core';
import {NetexControllerService} from '../netex-controller/netex-controller.service';
-import {DrugstoneConfigService} from "../drugstone-config/drugstone-config.service";
-import {NetworkHandlerService} from "../network-handler/network-handler.service";
-import { ToastService } from '../toast/toast.service';
-import { NodeGroup } from 'src/app/config';
+import {DrugstoneConfigService} from '../drugstone-config/drugstone-config.service';
+import {NetworkHandlerService} from '../network-handler/network-handler.service';
+import {ToastService} from '../toast/toast.service';
+import {NodeGroup} from 'src/app/config';
export type AlgorithmType =
'trustrank'
@@ -74,11 +74,11 @@ export class AnalysisService {
private tissues: Tissue[] = [];
constructor(
- public toast: ToastService,
- private http: HttpClient,
- public netex: NetexControllerService,
- public drugstoneConfig: DrugstoneConfigService,
- public networkHandler: NetworkHandlerService
+ public toast: ToastService,
+ private http: HttpClient,
+ public netex: NetexControllerService,
+ public drugstoneConfig: DrugstoneConfigService,
+ public networkHandler: NetworkHandlerService
) {
const tokens = localStorage.getItem(this.tokensCookieKey);
const finishedTokens = localStorage.getItem(this.tokensFinishedCookieKey);
@@ -158,11 +158,11 @@ export class AnalysisService {
this.networkHandler.activeNetwork.currentViewNodes.forEach((node) => {
if (node.group !== group.groupID || node.drugstoneType !== 'protein') {
// only consider nodes of group and proteins
- return
+ return;
}
wrappers.push(getWrapperFromNode(node));
});
- this.addItems(wrappers)
+ this.addItems(wrappers);
}
public addAllToSelection() {
@@ -170,11 +170,11 @@ export class AnalysisService {
this.networkHandler.activeNetwork.currentViewNodes.forEach((node) => {
if (node.drugstoneType !== 'protein') {
// only consider proteins
- return
+ return;
}
wrappers.push(getWrapperFromNode(node));
});
- this.addItems(wrappers)
+ this.addItems(wrappers);
}
// public addSeeds(nodes) {
@@ -204,14 +204,14 @@ export class AnalysisService {
nodes.forEach((node: Node) => {
if (node.drugstoneType !== 'protein') {
// only consider proteins
- return
+ return;
}
const wrapper = getWrapperFromNode(node);
if (!this.inSelection(wrapper)) {
newSelection.push(wrapper);
}
});
- this.resetSelection()
+ this.resetSelection();
for (const wrapper of newSelection) {
this.selectedItems.set(wrapper.id, wrapper);
}
@@ -266,9 +266,9 @@ export class AnalysisService {
if (item.drugstoneType === 'protein') {
seeds.push(item.id);
}
- })
+ });
}
- const target = ['connect', 'connectSelected'].includes(algorithm) ? 'drug-target' : 'drug'
+ const target = ['connect', 'connectSelected'].includes(algorithm) ? 'drug-target' : 'drug';
const parameters: any = {
seeds: seeds,
config: this.drugstoneConfig.config,
@@ -296,7 +296,7 @@ export class AnalysisService {
' Once the computation finished you can view the results in the task list to the right.',
type: 'success'
});
- return { taskId: resp.token, algorithm: algorithm, target: target, params: parameters }
+ return {taskId: resp.token, algorithm: algorithm, target: target, params: parameters};
}
async startAnalysis(algorithm, target: 'drug' | 'drug-target', parameters) {
@@ -340,6 +340,13 @@ export class AnalysisService {
});
}
+ unmappedNodeToast() {
+ this.toast.setNewToast({
+ message: 'This node cannot be selected because either it could not be mapped correctly or it is not of type gene or protein.',
+ type: 'warning',
+ });
+ }
+
public canLaunchTask(): boolean {
return this.canLaunchNewTask;
}
@@ -348,8 +355,9 @@ export class AnalysisService {
const watch = async () => {
if (this.tokens.length > 0) {
const newtasks = await this.getTasks();
- if (newtasks.length === 0)
+ if (newtasks.length === 0) {
return;
+ }
const newTaskIds = newtasks.map(t => t.token.toString());
this.tasks = newtasks.concat(this.tasks.filter(t => newTaskIds.indexOf(t.token) === -1));
if (!this.tasks) {
diff --git a/src/index.html b/src/index.html
index dec73108de81818de01e0d1b9bc5b810044f3bb4..5a5acd8dacf9aad1b4391023fe485520502d982b 100644
--- a/src/index.html
+++ b/src/index.html
@@ -95,7 +95,7 @@
<drugst-one id="netexp1"
pluginId="2"
groups='{"nodeGroups":{"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Seed","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#f0f0f0"},"groupName":"Discovered target","shape":"circle"},"foundDrug":{"type":"drug","color":"#F12590","font":{"color":"#000000"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"default":{"color":"#000000","groupName":"default edge"}}}'
- config='{"identifier":"symbol","title":"ROBUST output network", "taskDrugName": "Drug Search", "showLegendNodes": true, "showLegendEdges": true, "showSidebar": "left", "showOverview": true, "legendPos": "left", "legendClass": "legend", "showQuery": true, "showItemSelector": true,"showSimpleAnalysis": false,"showAdvAnalysis": true,"showSelection": true,"showTasks": true,"showNetworkMenu": "right","showLegend": true,"showNetworkMenuButtonExpression": true, "showNetworkMenuButtonScreenshot": true,"showNetworkMenuButtonExportGraphml": true,"showNetworkMenuButtonAdjacentDrugs": true,"showNetworkMenuButtonCenter": true,"showConnectGenes": false,"networkMenuButtonAdjacentDrugsLabel": "Drugs","showNetworkMenuButtonAdjacentDisordersProteins": true,"networkMenuButtonAdjacentDisordersProteinsLabel": "Disorders (protein)","showNetworkMenuButtonAdjacentDisordersDrugs": true,"networkMenuButtonAdjacentDisordersDrugsLabel": "Disorders (drug)","showNetworkMenuButtonAnimation": true,"networkMenuButtonAnimationLabel": "Animation", "autofillEdges": false, "physicsOn": false,"useNedrexLicenced": true,"selfReferences": false, "interactionDrugProtein": "NeDRex", "indicationDrugDisorder": "NeDRex","nodeShadow": true,"edgeShadow": true, "algorithms": {"drug": ["trustrank", "closeness", "degree", "proximity"], "drug-target": ["trustrank", "multisteiner", "keypathwayminer", "degree", "closeness", "betweenness"]}, "associatedProteinDisorder": "NeDRex", "expandNetworkMenu": true}'
+ config='{ "identifier":"symbol","title":"ROBUST output network", "taskDrugName": "Drug Search", "showLegendNodes": true, "showLegendEdges": true, "showSidebar": "left", "showOverview": true, "legendPos": "left", "legendClass": "legend", "showQuery": true, "showItemSelector": true,"showSimpleAnalysis": false,"showAdvAnalysis": true,"showSelection": true,"showTasks": true,"showNetworkMenu": "right","showLegend": true,"showNetworkMenuButtonExpression": true, "showNetworkMenuButtonScreenshot": true,"showNetworkMenuButtonExportGraphml": true,"showNetworkMenuButtonAdjacentDrugs": true,"showNetworkMenuButtonCenter": true,"showConnectGenes": false,"networkMenuButtonAdjacentDrugsLabel": "Drugs","showNetworkMenuButtonAdjacentDisordersProteins": true,"networkMenuButtonAdjacentDisordersProteinsLabel": "Disorders (protein)","showNetworkMenuButtonAdjacentDisordersDrugs": true,"networkMenuButtonAdjacentDisordersDrugsLabel": "Disorders (drug)","showNetworkMenuButtonAnimation": true,"networkMenuButtonAnimationLabel": "Animation", "autofillEdges": false, "physicsOn": false,"useNedrexLicenced": true,"selfReferences": false, "interactionDrugProtein": "NeDRex", "indicationDrugDisorder": "NeDRex","nodeShadow": true,"edgeShadow": true, "algorithms": {"drug": ["trustrank", "closeness", "degree", "proximity"], "drug-target": ["trustrank", "multisteiner", "keypathwayminer", "degree", "closeness", "betweenness"]}, "associatedProteinDisorder": "NeDRex", "expandNetworkMenu": true}'
network='{"nodes": [{"id": "UBE2I", "group": "gene"}, {"id": "EEF1A1", "group": "gene"}, {"id": "KDM5A", "group": "gene"}, {"id": "THOC2", "group": "gene"}, {"id": "XPO1", "group": "gene"}, {"id": "RPL4", "group": "gene"}, {"id": "TOP1", "group": "gene"}, {"id": "YWHAE", "group": "gene"}, {"id": "CHUK", "group": "gene"}, {"id": "HSP90AB1", "group": "gene"}, {"id": "CD6", "group": "important"}, {"id": "TYK2", "group": "important"}, {"id": "FSTL1", "group": "gene"}, {"id": "CBL", "group": "gene"}, {"id": "NR2F2", "group": "gene"}, {"id": "RUNX1T1", "group": "gene"}, {"id": "MED23", "group": "gene"}, {"id": "IFNAR1", "group": "gene"}, {"id": "LCOR", "group": "gene"}, {"id": "IL10", "group": "important"}, {"id": "NLRP3", "group": "important"}, {"id": "A2M", "group": "gene"}, {"id": "EIF4A1", "group": "gene"}, {"id": "HSPA4", "group": "gene"}, {"id": "ACTB", "group": "gene"}, {"id": "SNRPB", "group": "gene"}, {"id": "KIF1B", "group": "important"}, {"id": "HIST1H1B", "group": "gene"}, {"id": "EFNB3", "group": "gene"}, {"id": "ERP44", "group": "gene"}, {"id": "HSP90AA1", "group": "gene"}, {"id": "KIF2C", "group": "gene"}, {"id": "KCNJ10", "group": "important"}, {"id": "APOE", "group": "important"}, {"id": "RNF14", "group": "gene"}, {"id": "TM9SF1", "group": "gene"}, {"id": "TRIM28", "group": "gene"}, {"id": "RIPK2", "group": "gene"}, {"id": "IL1R1", "group": "gene"}, {"id": "IL1B", "group": "important"}, {"id": "PRDX2", "group": "gene"}, {"id": "GOPC", "group": "gene"}, {"id": "ARHGEF7", "group": "gene"}, {"id": "CASK", "group": "gene"}, {"id": "MYC", "group": "gene"}, {"id": "SNW1", "group": "gene"}, {"id": "KRT31", "group": "gene"}, {"id": "TSSC1", "group": "gene"}, {"id": "LRP2", "group": "gene"}, {"id": "VCAM1", "group": "important"}, {"id": "CRK", "group": "gene"}, {"id": "LGALS3BP", "group": "gene"}, {"id": "PCMT1", "group": "gene"}, {"id": "MLLT4", "group": "gene"}, {"id": "BRCA1", "group": "gene"}, {"id": "IL7R", "group": "important"}, {"id": "BAG1", "group": "gene"}, {"id": "RAB3B", "group": "gene"}, {"id": "MAPK1", "group": "gene"}, {"id": "CPSF7", "group": "gene"}, {"id": "STAT1", "group": "gene"}, {"id": "HLA-DPB1", "group": "important"}, {"id": "NCOR2", "group": "gene"}, {"id": "IL7", "group": "important"}, {"id": "TNFAIP3", "group": "important"}, {"id": "RNF31", "group": "gene"}, {"id": "IRF8", "group": "important"}, {"id": "PTPN11", "group": "gene"}, {"id": "CLEC16A", "group": "important"}, {"id": "BIRC3", "group": "gene"}, {"id": "DEFA1", "group": "gene"}, {"id": "POMC", "group": "important"}, {"id": "UBR4", "group": "gene"}, {"id": "SMARCA5", "group": "gene"}, {"id": "SEC24A", "group": "gene"}, {"id": "ADRB2", "group": "gene"}, {"id": "COPS2", "group": "gene"}, {"id": "TRAF3IP2", "group": "gene"}, {"id": "RBPJ", "group": "important"}, {"id": "RAB39B", "group": "gene"}, {"id": "NCOA6", "group": "gene"}, {"id": "IFNG", "group": "important"}, {"id": "SIAH1", "group": "gene"}, {"id": "CD58", "group": "important"}, {"id": "KRTAP10-8", "group": "gene"}, {"id": "WRAP73", "group": "gene"}, {"id": "FYN", "group": "gene"}, {"id": "GNAI2", "group": "gene"}, {"id": "YWHAH", "group": "gene"}, {"id": "CBLB", "group": "important"}, {"id": "IL2RA", "group": "important"}, {"id": "P2RX7", "group": "important"}, {"id": "CCND3", "group": "gene"}, {"id": "MCAM", "group": "important"}, {"id": "YBX3", "group": "gene"}, {"id": "IL1RN", "group": "important"}, {"id": "IFNB1", "group": "important"}, {"id": "FAF1", "group": "gene"}, {"id": "SPDL1", "group": "gene"}, {"id": "ELAVL1", "group": "gene"}, {"id": "IL12A", "group": "important"}, {"id": "LGALS8", "group": "gene"}, {"id": "GNAI3", "group": "gene"}, {"id": "VDR", "group": "important"}, {"id": "SNTA1", "group": "gene"}, {"id": "TNFRSF1A", "group": "important"}, {"id": "CD40", "group": "important"}, {"id": "RAP1GAP", "group": "gene"}, {"id": "PDGFRB", "group": "gene"}, {"id": "SELE", "group": "important"}, {"id": "VCL", "group": "gene"}, {"id": "IFI16", "group": "gene"}, {"id": "YWHAB", "group": "gene"}, {"id": "IL17A", "group": "important"}, {"id": "KIF11", "group": "gene"}, {"id": "GRB2", "group": "gene"}, {"id": "CNR1", "group": "important"}, {"id": "RELA", "group": "gene"}, {"id": "HSPA8", "group": "gene"}, {"id": "STAT4", "group": "important"}, {"id": "SND1", "group": "gene"}, {"id": "LRP8", "group": "gene"}, {"id": "GNAI1", "group": "gene"}, {"id": "F11R", "group": "gene"}, {"id": "HNRNPC", "group": "gene"}, {"id": "COPS5", "group": "gene"}, {"id": "ACTA2", "group": "gene"}, {"id": "FLNA", "group": "gene"}, {"id": "CSNK2A1", "group": "gene"}, {"id": "JUN", "group": "gene"}, {"id": "VDAC1", "group": "gene"}, {"id": "PSMC5", "group": "gene"}, {"id": "IL12B", "group": "gene"}, {"id": "SLAMF1", "group": "gene"}, {"id": "HLA-DRA", "group": "important"}, {"id": "APP", "group": "gene"}, {"id": "HLA-DPA1", "group": "gene"}, {"id": "BCHE", "group": "important"}, {"id": "ICAM1", "group": "important"}, {"id": "NLRC4", "group": "gene"}, {"id": "RNF41", "group": "gene"}, {"id": "COL14A1", "group": "gene"}, {"id": "YWHAG", "group": "gene"}, {"id": "MS4A1", "group": "gene"}, {"id": "SF1", "group": "gene"}, {"id": "CASP10", "group": "gene"}, {"id": "TP53", "group": "gene"}, {"id": "GC", "group": "important"}, {"id": "TRAF6", "group": "gene"}, {"id": "CASP1", "group": "important"}], "edges": [{"from": "UBE2I", "to": "KIF1B", "group": "default"}, {"from": "UBE2I", "to": "TNFRSF1A", "group": "default"}, {"from": "EEF1A1", "to": "VCAM1", "group": "default"}, {"from": "EEF1A1", "to": "KIF1B", "group": "default"}, {"from": "KDM5A", "to": "RBPJ", "group": "default"}, {"from": "KDM5A", "to": "VDR", "group": "default"}, {"from": "THOC2", "to": "VCAM1", "group": "default"}, {"from": "THOC2", "to": "KIF1B", "group": "default"}, {"from": "XPO1", "to": "RBPJ", "group": "default"}, {"from": "XPO1", "to": "VCAM1", "group": "default"}, {"from": "XPO1", "to": "RAP1GAP", "group": "default"}, {"from": "RPL4", "to": "APOE", "group": "default"}, {"from": "RPL4", "to": "ICAM1", "group": "default"}, {"from": "RPL4", "to": "VCAM1", "group": "default"}, {"from": "TOP1", "to": "NLRP3", "group": "default"}, {"from": "TOP1", "to": "IL7R", "group": "default"}, {"from": "TOP1", "to": "IRF8", "group": "default"}, {"from": "YWHAE", "to": "TNFAIP3", "group": "default"}, {"from": "YWHAE", "to": "HLA-DRA", "group": "default"}, {"from": "YWHAE", "to": "KIF1B", "group": "default"}, {"from": "CHUK", "to": "CD40", "group": "default"}, {"from": "CHUK", "to": "TNFRSF1A", "group": "default"}, {"from": "HSP90AB1", "to": "HLA-DRA", "group": "default"}, {"from": "HSP90AB1", "to": "VCAM1", "group": "default"}, {"from": "CD6", "to": "MYC", "group": "default"}, {"from": "TYK2", "to": "COPS5", "group": "default"}, {"from": "TYK2", "to": "IFNAR1", "group": "default"}, {"from": "TYK2", "to": "TRIM28", "group": "default"}, {"from": "TYK2", "to": "LGALS3BP", "group": "default"}, {"from": "TYK2", "to": "FYN", "group": "default"}, {"from": "TYK2", "to": "CBL", "group": "default"}, {"from": "TYK2", "to": "LRP8", "group": "default"}, {"from": "FSTL1", "to": "IL12A", "group": "default"}, {"from": "FSTL1", "to": "DEFA1", "group": "default"}, {"from": "CBL", "to": "IRF8", "group": "default"}, {"from": "CBL", "to": "TNFRSF1A", "group": "default"}, {"from": "NR2F2", "to": "RBPJ", "group": "default"}, {"from": "NR2F2", "to": "GC", "group": "default"}, {"from": "RUNX1T1", "to": "VDR", "group": "default"}, {"from": "RUNX1T1", "to": "RBPJ", "group": "default"}, {"from": "MED23", "to": "RBPJ", "group": "default"}, {"from": "MED23", "to": "VDR", "group": "default"}, {"from": "IFNAR1", "to": "IFNB1", "group": "default"}, {"from": "LCOR", "to": "RBPJ", "group": "default"}, {"from": "LCOR", "to": "VDR", "group": "default"}, {"from": "IL10", "to": "A2M", "group": "default"}, {"from": "NLRP3", "to": "FAF1", "group": "default"}, {"from": "NLRP3", "to": "YBX3", "group": "default"}, {"from": "NLRP3", "to": "HNRNPC", "group": "default"}, {"from": "NLRP3", "to": "SNRPB", "group": "default"}, {"from": "NLRP3", "to": "NLRC4", "group": "default"}, {"from": "NLRP3", "to": "HIST1H1B", "group": "default"}, {"from": "NLRP3", "to": "SMARCA5", "group": "default"}, {"from": "NLRP3", "to": "HSP90AA1", "group": "default"}, {"from": "A2M", "to": "IL1B", "group": "default"}, {"from": "A2M", "to": "APOE", "group": "default"}, {"from": "EIF4A1", "to": "VCAM1", "group": "default"}, {"from": "EIF4A1", "to": "KIF1B", "group": "default"}, {"from": "HSPA4", "to": "CD40", "group": "default"}, {"from": "HSPA4", "to": "KCNJ10", "group": "default"}, {"from": "ACTB", "to": "GC", "group": "default"}, {"from": "ACTB", "to": "ICAM1", "group": "default"}, {"from": "SNRPB", "to": "ICAM1", "group": "default"}, {"from": "KIF1B", "to": "YWHAH", "group": "default"}, {"from": "KIF1B", "to": "GOPC", "group": "default"}, {"from": "KIF1B", "to": "YWHAG", "group": "default"}, {"from": "KIF1B", "to": "SIAH1", "group": "default"}, {"from": "KIF1B", "to": "SEC24A", "group": "default"}, {"from": "KIF1B", "to": "BRCA1", "group": "default"}, {"from": "KIF1B", "to": "YWHAB", "group": "default"}, {"from": "KIF1B", "to": "ELAVL1", "group": "default"}, {"from": "HIST1H1B", "to": "VCAM1", "group": "default"}, {"from": "EFNB3", "to": "P2RX7", "group": "default"}, {"from": "ERP44", "to": "CD40", "group": "default"}, {"from": "ERP44", "to": "IL12B", "group": "default"}, {"from": "HSP90AA1", "to": "TNFAIP3", "group": "default"}, {"from": "HSP90AA1", "to": "HLA-DRA", "group": "default"}, {"from": "KIF2C", "to": "RBPJ", "group": "default"}, {"from": "KIF2C", "to": "TNFRSF1A", "group": "default"}, {"from": "KCNJ10", "to": "HSPA8", "group": "default"}, {"from": "KCNJ10", "to": "APP", "group": "default"}, {"from": "KCNJ10", "to": "BAG1", "group": "default"}, {"from": "KCNJ10", "to": "SNTA1", "group": "default"}, {"from": "KCNJ10", "to": "SIAH1", "group": "default"}, {"from": "KCNJ10", "to": "SEC24A", "group": "default"}, {"from": "APOE", "to": "LRP2", "group": "default"}, {"from": "APOE", "to": "ELAVL1", "group": "default"}, {"from": "APOE", "to": "HLA-DPA1", "group": "default"}, {"from": "APOE", "to": "CSNK2A1", "group": "default"}, {"from": "APOE", "to": "PCMT1", "group": "default"}, {"from": "APOE", "to": "LRP8", "group": "default"}, {"from": "APOE", "to": "PRDX2", "group": "default"}, {"from": "APOE", "to": "VDAC1", "group": "default"}, {"from": "RNF14", "to": "TNFAIP3", "group": "default"}, {"from": "RNF14", "to": "VDR", "group": "default"}, {"from": "TM9SF1", "to": "P2RX7", "group": "default"}, {"from": "TRIM28", "to": "STAT4", "group": "default"}, {"from": "TRIM28", "to": "VCAM1", "group": "default"}, {"from": "RIPK2", "to": "CASP1", "group": "default"}, {"from": "RIPK2", "to": "TNFRSF1A", "group": "default"}, {"from": "RIPK2", "to": "CD40", "group": "default"}, {"from": "IL1R1", "to": "IL1RN", "group": "default"}, {"from": "IL1R1", "to": "IL1B", "group": "default"}, {"from": "IL1B", "to": "ELAVL1", "group": "default"}, {"from": "IL1B", "to": "APP", "group": "default"}, {"from": "IL1B", "to": "CASP1", "group": "default"}, {"from": "IL1B", "to": "FYN", "group": "default"}, {"from": "PRDX2", "to": "VCAM1", "group": "default"}, {"from": "GOPC", "to": "IFNG", "group": "default"}, {"from": "ARHGEF7", "to": "CBLB", "group": "default"}, {"from": "ARHGEF7", "to": "ICAM1", "group": "default"}, {"from": "CASK", "to": "P2RX7", "group": "default"}, {"from": "MYC", "to": "VDR", "group": "default"}, {"from": "MYC", "to": "RBPJ", "group": "default"}, {"from": "SNW1", "to": "RBPJ", "group": "default"}, {"from": "SNW1", "to": "VDR", "group": "default"}, {"from": "KRT31", "to": "P2RX7", "group": "default"}, {"from": "TSSC1", "to": "CLEC16A", "group": "default"}, {"from": "LRP2", "to": "GC", "group": "default"}, {"from": "VCAM1", "to": "VCL", "group": "default"}, {"from": "VCAM1", "to": "CPSF7", "group": "default"}, {"from": "VCAM1", "to": "MLLT4", "group": "default"}, {"from": "VCAM1", "to": "UBR4", "group": "default"}, {"from": "VCAM1", "to": "SND1", 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>
</drugst-one>