diff --git a/src/app/config.ts b/src/app/config.ts index 0045a293e3dca091db260df7f985c1d5992736a7..3479c048d4542ae6bc63be66eb3b770fd21800f5 100644 --- a/src/app/config.ts +++ b/src/app/config.ts @@ -24,8 +24,11 @@ export interface EdgeGroup { } export type Identifier = 'symbol'|'uniprot'|'ensg'; -export type InteractionDrugProteinDB = 'DrugBank'|'Chembl'|'DGIdb'; -export type InteractionProteinProteinDB = 'STRING'|'BioGRID'|'APID'; +export type InteractionDrugProteinDB = 'DrugBank'|'Chembl'|'DGIdb' | 'NeDRex'; +export type InteractionProteinProteinDB = 'STRING'|'BioGRID'|'APID' | 'NeDRex'; +export type IndicationDrugDisorderDB = 'DrugBank' | 'NeDRex'; +export type AssociatedProteinDisorderDB = 'NeDRex' | 'DisGeNET'; + // TODO: should this be external or integrated in the backend? export type InteractionDatabase = 'omnipath'; @@ -35,8 +38,8 @@ export interface IConfig { legendUrl: string; legendClass: string; legendPos: 'left' | 'right'; - taskTargetName: string, - taskDrugName: string, + taskTargetName: string; + taskDrugName: string; showSidebar: false | 'left' | 'right'; showOverview: boolean; showQuery: boolean; @@ -65,6 +68,8 @@ export interface IConfig { edgeGroups: { [key: string]: EdgeGroup }; interactionDrugProtein: InteractionDrugProteinDB; interactionProteinProtein: InteractionProteinProteinDB; + indicationDrugDisorder: IndicationDrugDisorderDB; + associatedProteinDisorder: AssociatedProteinDisorderDB; autofillEdges: boolean; interactions?: InteractionDatabase; physicsOn?: boolean; @@ -108,8 +113,10 @@ export const defaultConfig: IConfig = { showNetworkMenuButtonAnimation: true, networkMenuButtonAnimationLabel: 'Animation', identifier: 'symbol', - interactionDrugProtein: 'DrugBank', - interactionProteinProtein: 'STRING', + interactionDrugProtein: 'NeDRex', + interactionProteinProtein: 'NeDRex', + associatedProteinDisorder: 'NeDRex', + indicationDrugDisorder: 'NeDRex', nodeShadow: true, edgeShadow: true, autofillEdges: true, @@ -226,5 +233,5 @@ export const defaultConfig: IConfig = { color: 'black', dashes: false } - }, + } }; diff --git a/src/index.html b/src/index.html index 903991b5fd1e4a57789e293bcb8e65cb1b813609..3614e49c4dc7d4321b0af6c76dc5da496f6f46ad 100644 --- a/src/index.html +++ b/src/index.html @@ -49,7 +49,7 @@ <drugst-one id="netexp1" pluginId="2" - config='{"physicsOn":true, "showLeftSidebar": true, "showSimpleAnalysis":true, "nodeGroups":{"patient":{"type":"patient","color":"black","font":{"color":"#ffffff"},"groupName":"Patient","shape":"image","image":"https://static.thenounproject.com/png/22780-200.png"},"condition":{"type":"condition","color":"black","font":{"color":"black"},"groupName":"Condition","shape":"text"},"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Important Gene","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#ffffff"},"groupName":"Gene","shape":"circle"},"foundDrug":{"type":"drug","color":{"border":"#F12590","background":"#F12590"},"font":{"color":"#f0f0f0"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"genotype":{"color":"black","groupName":"Relevant Gene"},"has-condition":{"color":"#000000","groupName":"Has Condition","dashes":[2,2]},"default":{"color":"#000000","groupName":"default edge"},"ggi":{"color":"#000000","groupName":"Interaction","dashes":[3,2]}},"identifier":"symbol","title":"Breast cancer example network","nodeShadow":true,"edgeShadow":false,"autofillEdges":false,"showLegend":true}' + config='{"interactionDrugProtein":"NeDRex", "physicsOn":true, "showLeftSidebar": true, "showSimpleAnalysis":true, "nodeGroups":{"patient":{"type":"patient","color":"black","font":{"color":"#ffffff"},"groupName":"Patient","shape":"image","image":"https://static.thenounproject.com/png/22780-200.png"},"condition":{"type":"condition","color":"black","font":{"color":"black"},"groupName":"Condition","shape":"text"},"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Important Gene","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#ffffff"},"groupName":"Gene","shape":"circle"},"foundDrug":{"type":"drug","color":{"border":"#F12590","background":"#F12590"},"font":{"color":"#f0f0f0"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"genotype":{"color":"black","groupName":"Relevant Gene"},"has-condition":{"color":"#000000","groupName":"Has Condition","dashes":[2,2]},"default":{"color":"#000000","groupName":"default edge"},"ggi":{"color":"#000000","groupName":"Interaction","dashes":[3,2]}},"identifier":"symbol","title":"Breast cancer example network","nodeShadow":true,"edgeShadow":false,"autofillEdges":false,"showLegend":true}' network='{"nodes":[{"id":"patient-1","group":"patient","x":592,"y":446},{"id":"patient-2","group":"patient","x":235,"y":87},{"id":"patient-3","group":"patient","x":105,"y":369},{"id":"ATM","label":"ATM","group":"gene","x":289,"y":242},{"id":"BARD1","label":"BARD1","group":"gene","x":44,"y":250},{"id":"BRCA1","label":"BRCA1","group":"gene","x":466,"y":576},{"id":"BRCA2","label":"BRCA2","group":"gene","x":507,"y":285},{"id":"BRIP1","label":"BRIP1","group":"gene","x":54,"y":474},{"id":"CHEK2","label":"CHEK2","group":"gene","x":216,"y":590},{"id":"CDH1","label":"CDH1","group":"gene","x":320,"y":-57},{"id":"NF1","label":"NF1","group":"gene","x":481,"y":111},{"id":"NBN","label":"NBN","group":"gene","x":-57,"y":314},{"id":"PALB2","label":"PALB2","group":"gene","x":450,"y":190},{"id":"PTEN","label":"PTEN","group":"important","x":305,"y":494},{"id":"RAD51C","label":"RAD51C","group":"gene","x":182,"y":-90},{"id":"RAD51D","label":"RAD51D","group":"gene","x":368,"y":73},{"id":"STK11","label":"STK11","group":"gene","x":686,"y":330},{"id":"TP53","label":"TP53","group":"important","x":333,"y":316},{"id":"subtype-1","label":"Subtype 1","group":"condition","x":556,"y":171},{"id":"subtype-2","label":"Subtype 2","group":"condition","x":-87,"y":221}],"edges":[{"from":"BRCA1","to":"BRCA2","group":"ggi"},{"from":"ATM","to":"BARD1","group":"ggi"},{"from":"BRCA1","to":"CHEK2","group":"ggi"},{"from":"RAD51C","to":"RAD51D","group":"ggi"},{"from":"STK11","to":"TP53","group":"ggi"},{"from":"TP53","to":"PALB2","group":"ggi"},{"from":"TP53","to":"RAD51D","group":"ggi"},{"from":"TP53","to":"NF1","group":"ggi"},{"from":"TP53","to":"BRCA1","group":"ggi"},{"from":"TP53","to":"BRCA2","group":"ggi"},{"from":"PTEN","to":"BRCA1","group":"ggi"},{"from":"PTEN","to":"BRCA2","group":"ggi"},{"from":"TP53","to":"PTEN","group":"ggi"},{"from":"ATM","to":"PTEN","group":"ggi"},{"from":"CDH1","to":"RAD51D","group":"ggi"},{"from":"CDH1","to":"PALB2","group":"ggi"},{"from":"NBN","to":"BRIP1","group":"ggi"},{"from":"BRIP1","to":"PTEN","group":"ggi"},{"from":"patient-1","to":"BRCA1","group":"genotype"},{"from":"patient-1","to":"TP53","group":"genotype"},{"from":"patient-1","to":"BRCA2","group":"genotype"},{"from":"patient-1","to":"PTEN","group":"genotype"},{"from":"patient-2","to":"TP53","group":"genotype"},{"from":"patient-2","to":"NF1","group":"genotype"},{"from":"patient-2","to":"BARD1","group":"genotype"},{"from":"patient-3","to":"TP53","group":"genotype"},{"from":"patient-3","to":"PTEN","group":"genotype"},{"from":"patient-3","to":"NBN","group":"genotype"},{"from":"patient-1","to":"subtype-1","group":"has-condition"},{"from":"patient-2","to":"subtype-1","group":"has-condition"},{"from":"patient-3","to":"subtype-2","group":"has-condition"}]}'> </drugst-one> </div>