diff --git a/src/app/components/analysis-panel/analysis-panel.component.html b/src/app/components/analysis-panel/analysis-panel.component.html
index 76655a32d9336c81deb5bbaf55f5b67324685b39..31cbbf764cf1044bd158d67d0b1d3750e89e69f2 100644
--- a/src/app/components/analysis-panel/analysis-panel.component.html
+++ b/src/app/components/analysis-panel/analysis-panel.component.html
@@ -114,14 +114,13 @@
>
<td>Include indirect drugs</td>
<td>
- <i
- *ngIf="task.info.parameters.includeIndirectDrugs"
- class="fa fa-check"
- ></i>
- <i
- *ngIf="!task.info.parameters.includeIndirectDrugs"
- class="fa fa-times"
- ></i>
+ <span *ngIf="task.info.parameters.includeIndirectDrugs">
+ <i class="fa fa-check"></i>
+ </span>
+ <span *ngIf="!task.info.parameters.includeIndirectDrugs">
+ <i class="fa fa-times"></i>
+ </span>
+
</td>
</tr>
<tr
@@ -132,14 +131,12 @@
>
<td>Include non-approved drugs</td>
<td>
- <i
- *ngIf="task.info.parameters.includeNonApprovedDrugs"
- class="fa fa-check"
- ></i>
- <i
- *ngIf="!task.info.parameters.includeNonApprovedDrugs"
- class="fa fa-times"
- ></i>
+ <span *ngIf="task.info.parameters.includeNonApprovedDrugs">
+ <i class="fa fa-check"></i>
+ </span>
+ <span *ngIf="!task.info.parameters.includeNonApprovedDrugs">
+ <i class="fa fa-times"></i>
+ </span>
</td>
</tr>
</tbody>
diff --git a/src/app/components/network/network.component.ts b/src/app/components/network/network.component.ts
index 5be2c33c93bc3ff7624ffce882308d0318e7cfe5..442831fd3552595f5dfc588c26f2775c6ceb24f5 100644
--- a/src/app/components/network/network.component.ts
+++ b/src/app/components/network/network.component.ts
@@ -1,10 +1,10 @@
-import { Component, ElementRef, Input, OnInit, ViewChild } from '@angular/core';
+import {Component, ElementRef, Input, OnInit, ViewChild} from '@angular/core';
import domtoimage from 'dom-to-image';
-import { InteractionDatabase } from 'src/app/config';
-import { DrugstoneConfigService } from 'src/app/services/drugstone-config/drugstone-config.service';
-import { NetexControllerService } from 'src/app/services/netex-controller/netex-controller.service';
-import { OmnipathControllerService } from 'src/app/services/omnipath-controller/omnipath-controller.service';
-import { mapCustomEdge, mapCustomNode, mapNetexEdge, ProteinNetwork } from '../../main-network';
+import {InteractionDatabase} from 'src/app/config';
+import {DrugstoneConfigService} from 'src/app/services/drugstone-config/drugstone-config.service';
+import {NetexControllerService} from 'src/app/services/netex-controller/netex-controller.service';
+import {OmnipathControllerService} from 'src/app/services/omnipath-controller/omnipath-controller.service';
+import {mapCustomEdge, mapCustomNode, mapNetexEdge, ProteinNetwork} from '../../main-network';
import {
getDrugNodeId,
getWrapperFromNode,
@@ -17,10 +17,10 @@ import {
Wrapper,
NetworkType
} from '../../interfaces';
-import { AnalysisService } from 'src/app/services/analysis/analysis.service';
-import { NetworkSettings } from 'src/app/network-settings';
-import { pieChartContextRenderer } from 'src/app/utils';
-import { NetworkHandlerService } from 'src/app/services/network-handler/network-handler.service';
+import {AnalysisService} from 'src/app/services/analysis/analysis.service';
+import {NetworkSettings} from 'src/app/network-settings';
+import {pieChartContextRenderer} from 'src/app/utils';
+import {NetworkHandlerService} from 'src/app/services/network-handler/network-handler.service';
@Component({
@@ -35,8 +35,8 @@ export class NetworkComponent implements OnInit {
@Input() public legendContext: LegendContext;
- @ViewChild('network', { static: false }) networkEl: ElementRef;
- @ViewChild('networkWithLegend', { static: false }) networkWithLegendEl: ElementRef;
+ @ViewChild('network', {static: false}) networkEl: ElementRef;
+ @ViewChild('networkWithLegend', {static: false}) networkWithLegendEl: ElementRef;
public networkInternal: any = null;
@@ -78,7 +78,8 @@ export class NetworkComponent implements OnInit {
public gradientMap: NodeAttributeMap = {};
- constructor(public networkHandler: NetworkHandlerService, public analysis: AnalysisService, public drugstoneConfig: DrugstoneConfigService, public netex: NetexControllerService, public omnipath: OmnipathControllerService) { }
+ constructor(public networkHandler: NetworkHandlerService, public analysis: AnalysisService, public drugstoneConfig: DrugstoneConfigService, public netex: NetexControllerService, public omnipath: OmnipathControllerService) {
+ }
ngOnInit(): void {
this.networkHandler.networks[this.networkType] = this;
@@ -114,7 +115,7 @@ export class NetworkComponent implements OnInit {
if (this.adjacentDisordersProtein) {
this.netex.adjacentDisorders(this.nodeData.nodes, 'proteins', this.drugstoneConfig.config.associatedProteinDisorder).subscribe(response => {
for (const interaction of response.edges) {
- const edge = { from: interaction.protein, to: interaction.disorder };
+ const edge = {from: interaction.protein, to: interaction.disorder};
this.adjacentProteinDisorderEdgesList.push(mapCustomEdge(edge, this.drugstoneConfig.config));
}
for (const disorder of response.disorders) {
@@ -142,7 +143,7 @@ export class NetworkComponent implements OnInit {
if (this.adjacentDisordersDrug) {
this.netex.adjacentDisorders(this.nodeData.nodes, 'drugs', this.drugstoneConfig.config.indicationDrugDisorder).subscribe(response => {
for (const interaction of response.edges) {
- const edge = { from: interaction.drug, to: interaction.disorder };
+ const edge = {from: interaction.drug, to: interaction.disorder};
this.adjacentDrugDisorderEdgesList.push(mapCustomEdge(edge, this.drugstoneConfig.config));
}
for (const disorder of response.disorders) {
@@ -168,16 +169,21 @@ export class NetworkComponent implements OnInit {
public updateAdjacentDrugs(bool: boolean) {
this.adjacentDrugs = bool;
if (this.adjacentDrugs) {
+ // console.log(this.nodeData.nodes)
this.netex.adjacentDrugs(this.drugstoneConfig.config.interactionDrugProtein, this.nodeData.nodes).subscribe(response => {
+ const existingDrugIDs = this.nodeData.nodes.get().filter(n => n.drugstoneId).map(n => n.drugstoneId);
for (const interaction of response.pdis) {
- const edge = { from: interaction.protein, to: interaction.drug };
+ const edge = {from: interaction.protein, to: interaction.drug};
this.adjacentDrugEdgesList.push(mapCustomEdge(edge, this.drugstoneConfig.config));
}
for (const drug of response.drugs) {
drug.group = 'foundDrug';
- drug.id = getDrugNodeId(drug)
- this.adjacentDrugList.push(mapCustomNode(drug, this.drugstoneConfig.config))
+ drug.id = getDrugNodeId(drug);
+ if (existingDrugIDs.indexOf(drug.drugstoneId) === -1) {
+ this.adjacentDrugList.push(mapCustomNode(drug, this.drugstoneConfig.config))
+ }
}
+
this.nodeData.nodes.add(this.adjacentDrugList);
this.nodeData.edges.add(this.adjacentDrugEdgesList);
this.updateQueryItems();
@@ -220,7 +226,7 @@ export class NetworkComponent implements OnInit {
}
public downloadDom(dom: object) {
- return domtoimage.toPng(dom, { bgcolor: '#ffffff' }).then((generatedImage) => {
+ return domtoimage.toPng(dom, {bgcolor: '#ffffff'}).then((generatedImage) => {
const a = document.createElement('a');
a.href = generatedImage;
a.download = `Network.png`;
@@ -254,7 +260,7 @@ export class NetworkComponent implements OnInit {
zoomScale = 3.0;
}
this.networkInternal.moveTo({
- position: { x: coords.x, y: coords.y },
+ position: {x: coords.x, y: coords.y},
scale: zoomScale,
animation: true,
});
diff --git a/src/app/config.ts b/src/app/config.ts
index 3479c048d4542ae6bc63be66eb3b770fd21800f5..ab90b6039b04bbb8c4b0f6dbf788e41281015c17 100644
--- a/src/app/config.ts
+++ b/src/app/config.ts
@@ -23,11 +23,11 @@ export interface EdgeGroup {
shadow?: any;
}
-export type Identifier = 'symbol'|'uniprot'|'ensg';
-export type InteractionDrugProteinDB = 'DrugBank'|'Chembl'|'DGIdb' | 'NeDRex';
-export type InteractionProteinProteinDB = 'STRING'|'BioGRID'|'APID' | 'NeDRex';
-export type IndicationDrugDisorderDB = 'DrugBank' | 'NeDRex';
-export type AssociatedProteinDisorderDB = 'NeDRex' | 'DisGeNET';
+export type Identifier = 'symbol' | 'uniprot' | 'ensg' | 'entrez';
+export type InteractionDrugProteinDB = 'NeDRex' | 'DrugBank' | 'Drug Central' | 'ChEMBL' | 'DGIdb';
+export type InteractionProteinProteinDB = 'NeDRex' | 'BioGRID' | 'IID' | 'IntAct' | 'STRING' | 'APID';
+export type IndicationDrugDisorderDB = 'NeDRex' | 'CTD' | 'Drug Central' | 'DrugBank';
+export type AssociatedProteinDisorderDB = 'NeDRex' | 'DisGeNET' | 'OMIM';
// TODO: should this be external or integrated in the backend?
diff --git a/src/app/dialogs/launch-analysis/launch-analysis.component.ts b/src/app/dialogs/launch-analysis/launch-analysis.component.ts
index bf4637eb5d15325dc9eeda8800f7053777777491..51dc79c8923579b41bbec7a762a5052305ac67a3 100644
--- a/src/app/dialogs/launch-analysis/launch-analysis.component.ts
+++ b/src/app/dialogs/launch-analysis/launch-analysis.component.ts
@@ -114,7 +114,6 @@ export class LaunchAnalysisComponent implements OnInit, OnChanges {
config: this.config,
input_network: this.inputNetwork
};
-
parameters.ppi_dataset = this.config.interactionProteinProtein;
parameters.pdi_dataset = this.config.interactionDrugProtein;
parameters.target = this.target === 'drug' ? 'drug' : 'drug-target';
diff --git a/src/index.html b/src/index.html
index 3614e49c4dc7d4321b0af6c76dc5da496f6f46ad..7da08bfc453c40b90b5848549596b016d8136a78 100644
--- a/src/index.html
+++ b/src/index.html
@@ -38,6 +38,48 @@
<input id="taskID" type="text" /> <button onclick=loadTaskID(document.getElementById("taskID").value) class="button is-primary" >Load TaskID</button> <br>
+<br>
+<br>
+<b>Datasets</b>
+<div>
+ <i>Protein-Protein Interactions</i>
+ <select name="Protein-Protein Interactions" onchange="applyDataset()" id="ppi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="BioGRID">BioGRID</option>
+ <option value="IID">IID</option>
+ <option value="IntAct">IntAct</option>
+ <option value="STRING">STRING</option>
+ <option value="APID">APID</option>
+ </select>
+</div>
+<div>
+ <i>Drug-Protein Targets</i>
+ <select name="Drug-Protein Targets" onchange="applyDataset()" id="drpi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="DrugBank">DrugBank</option>
+ <option value="Drug Central">Drug Central</option>
+ <option value="ChEMBL">ChEMBL</option>
+ <option value="DGIdb">DGIdb</option>
+ </select>
+</div>
+
+<div>
+ <i>Drug-Disorder Indications</i>
+ <select name="Drug-Disorder Indications" onchange="applyDataset()" id="drdi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="CTD">CTD</option>
+ <option value="Drug Central">Drug Central</option>
+ <option value="DrugBank">DrugBank</option>
+ </select>
+</div>
+<div>
+ <i>Protein-Disorder Associations</i>
+ <select name="Protein-Disorder Associations" onchange="applyDataset()" id="pdis-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="DisGeNET">CTD</option>
+ <option value="OMIM">Drug Central</option>
+ </select>
+</div>
<!--<input type="checkbox" onclick=changeConfigStr('{"showSimpleAnalysis":'+this.checked+'}') checked /> Show SimpleAnalysis<br>-->
@@ -49,8 +91,8 @@
<drugst-one id="netexp1"
pluginId="2"
- config='{"interactionDrugProtein":"NeDRex", "physicsOn":true, "showLeftSidebar": true, "showSimpleAnalysis":true, "nodeGroups":{"patient":{"type":"patient","color":"black","font":{"color":"#ffffff"},"groupName":"Patient","shape":"image","image":"https://static.thenounproject.com/png/22780-200.png"},"condition":{"type":"condition","color":"black","font":{"color":"black"},"groupName":"Condition","shape":"text"},"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Important Gene","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#ffffff"},"groupName":"Gene","shape":"circle"},"foundDrug":{"type":"drug","color":{"border":"#F12590","background":"#F12590"},"font":{"color":"#f0f0f0"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"genotype":{"color":"black","groupName":"Relevant Gene"},"has-condition":{"color":"#000000","groupName":"Has Condition","dashes":[2,2]},"default":{"color":"#000000","groupName":"default edge"},"ggi":{"color":"#000000","groupName":"Interaction","dashes":[3,2]}},"identifier":"symbol","title":"Breast cancer example network","nodeShadow":true,"edgeShadow":false,"autofillEdges":false,"showLegend":true}'
- network='{"nodes":[{"id":"patient-1","group":"patient","x":592,"y":446},{"id":"patient-2","group":"patient","x":235,"y":87},{"id":"patient-3","group":"patient","x":105,"y":369},{"id":"ATM","label":"ATM","group":"gene","x":289,"y":242},{"id":"BARD1","label":"BARD1","group":"gene","x":44,"y":250},{"id":"BRCA1","label":"BRCA1","group":"gene","x":466,"y":576},{"id":"BRCA2","label":"BRCA2","group":"gene","x":507,"y":285},{"id":"BRIP1","label":"BRIP1","group":"gene","x":54,"y":474},{"id":"CHEK2","label":"CHEK2","group":"gene","x":216,"y":590},{"id":"CDH1","label":"CDH1","group":"gene","x":320,"y":-57},{"id":"NF1","label":"NF1","group":"gene","x":481,"y":111},{"id":"NBN","label":"NBN","group":"gene","x":-57,"y":314},{"id":"PALB2","label":"PALB2","group":"gene","x":450,"y":190},{"id":"PTEN","label":"PTEN","group":"important","x":305,"y":494},{"id":"RAD51C","label":"RAD51C","group":"gene","x":182,"y":-90},{"id":"RAD51D","label":"RAD51D","group":"gene","x":368,"y":73},{"id":"STK11","label":"STK11","group":"gene","x":686,"y":330},{"id":"TP53","label":"TP53","group":"important","x":333,"y":316},{"id":"subtype-1","label":"Subtype 1","group":"condition","x":556,"y":171},{"id":"subtype-2","label":"Subtype 2","group":"condition","x":-87,"y":221}],"edges":[{"from":"BRCA1","to":"BRCA2","group":"ggi"},{"from":"ATM","to":"BARD1","group":"ggi"},{"from":"BRCA1","to":"CHEK2","group":"ggi"},{"from":"RAD51C","to":"RAD51D","group":"ggi"},{"from":"STK11","to":"TP53","group":"ggi"},{"from":"TP53","to":"PALB2","group":"ggi"},{"from":"TP53","to":"RAD51D","group":"ggi"},{"from":"TP53","to":"NF1","group":"ggi"},{"from":"TP53","to":"BRCA1","group":"ggi"},{"from":"TP53","to":"BRCA2","group":"ggi"},{"from":"PTEN","to":"BRCA1","group":"ggi"},{"from":"PTEN","to":"BRCA2","group":"ggi"},{"from":"TP53","to":"PTEN","group":"ggi"},{"from":"ATM","to":"PTEN","group":"ggi"},{"from":"CDH1","to":"RAD51D","group":"ggi"},{"from":"CDH1","to":"PALB2","group":"ggi"},{"from":"NBN","to":"BRIP1","group":"ggi"},{"from":"BRIP1","to":"PTEN","group":"ggi"},{"from":"patient-1","to":"BRCA1","group":"genotype"},{"from":"patient-1","to":"TP53","group":"genotype"},{"from":"patient-1","to":"BRCA2","group":"genotype"},{"from":"patient-1","to":"PTEN","group":"genotype"},{"from":"patient-2","to":"TP53","group":"genotype"},{"from":"patient-2","to":"NF1","group":"genotype"},{"from":"patient-2","to":"BARD1","group":"genotype"},{"from":"patient-3","to":"TP53","group":"genotype"},{"from":"patient-3","to":"PTEN","group":"genotype"},{"from":"patient-3","to":"NBN","group":"genotype"},{"from":"patient-1","to":"subtype-1","group":"has-condition"},{"from":"patient-2","to":"subtype-1","group":"has-condition"},{"from":"patient-3","to":"subtype-2","group":"has-condition"}]}'>
+ config='{"interactionDrugProtein":"NeDRex", "physicsOn":true, "showLeftSidebar": true, "showSimpleAnalysis":true, "nodeGroups":{"patient":{"type":"patient","color":"black","font":{"color":"#ffffff"},"groupName":"Patient","shape":"image","image":"https://static.thenounproject.com/png/22780-200.png"},"condition":{"type":"condition","color":"black","font":{"color":"black"},"groupName":"Condition","shape":"text"},"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Important Gene","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#ffffff"},"groupName":"Gene","shape":"circle"},"foundDrug":{"type":"drug","color":{"border":"#F12590","background":"#F12590"},"font":{"color":"#000000"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"genotype":{"color":"black","groupName":"Relevant Gene"},"has-condition":{"color":"#ffffff","groupName":"Has Condition","dashes":[2,2]},"default":{"color":"#000000","groupName":"default edge"},"ggi":{"color":"#000000","groupName":"Interaction","dashes":[3,2]}},"identifier":"symbol","title":"Breast cancer example network","nodeShadow":true,"edgeShadow":false,"autofillEdges":true,"showLegend":true}'
+ network='{"nodes":[{"id":"patient-1","group":"patient","x":592,"y":446},{"id":"patient-2","group":"patient","x":235,"y":87},{"id":"patient-3","group":"patient","x":105,"y":369},{"id":"ATM","label":"ATM","group":"gene","x":289,"y":242},{"id":"BARD1","label":"BARD1","group":"gene","x":44,"y":250},{"id":"BRCA1","label":"BRCA1","group":"gene","x":466,"y":576},{"id":"BRCA2","label":"BRCA2","group":"gene","x":507,"y":285},{"id":"BRIP1","label":"BRIP1","group":"gene","x":54,"y":474},{"id":"CHEK2","label":"CHEK2","group":"gene","x":216,"y":590},{"id":"CDH1","label":"CDH1","group":"gene","x":320,"y":-57},{"id":"NF1","label":"NF1","group":"gene","x":481,"y":111},{"id":"NBN","label":"NBN","group":"gene","x":-57,"y":314},{"id":"PALB2","label":"PALB2","group":"gene","x":450,"y":190},{"id":"PTEN","label":"PTEN","group":"important","x":305,"y":494},{"id":"RAD51C","label":"RAD51C","group":"gene","x":182,"y":-90},{"id":"RAD51D","label":"RAD51D","group":"gene","x":368,"y":73},{"id":"STK11","label":"STK11","group":"gene","x":686,"y":330},{"id":"TP53","label":"TP53","group":"important","x":333,"y":316},{"id":"subtype-1","label":"Subtype 1","group":"condition","x":556,"y":171},{"id":"subtype-2","label":"Subtype 2","group":"condition","x":-87,"y":221}],"edges":[{"from":"patient-1","to":"BRCA1","group":"genotype"},{"from":"patient-1","to":"TP53","group":"genotype"},{"from":"patient-1","to":"BRCA2","group":"genotype"},{"from":"patient-1","to":"PTEN","group":"genotype"},{"from":"patient-2","to":"TP53","group":"genotype"},{"from":"patient-2","to":"NF1","group":"genotype"},{"from":"patient-2","to":"BARD1","group":"genotype"},{"from":"patient-3","to":"TP53","group":"genotype"},{"from":"patient-3","to":"PTEN","group":"genotype"},{"from":"patient-3","to":"NBN","group":"genotype"},{"from":"patient-1","to":"subtype-1","group":"has-condition"},{"from":"patient-2","to":"subtype-1","group":"has-condition"},{"from":"patient-3","to":"subtype-2","group":"has-condition"}]}'>
</drugst-one>
</div>
@@ -102,6 +144,29 @@
document.getElementsByTagName("network-expander")[0].addEventListener("taskEvent",(event)=>{console.log(event.detail)})
}
+ function applyDataset(){
+ let ppi = document.getElementById('ppi-dataset')
+ setDataset('interactionProteinProtein',ppi.options[ppi.selectedIndex].value)
+ let drpi = document.getElementById('drpi-dataset')
+ setDataset('interactionDrugProtein', drpi.options[drpi.selectedIndex].value)
+ let drdi = document.getElementById('drdi-dataset')
+ setDataset('indicationDrugDisorder', drdi.options[drdi.selectedIndex].value)
+ let pdis = document.getElementById('pdis-dataset')
+ setDataset('associatedProteinDisorder', pdis.options[pdis.selectedIndex].value)
+
+
+ }
+
+ function setDataset(name, dataset){
+ // console.log(event)
+ console.log("Dataset "+name+" -> "+dataset)
+ const netexp = document.getElementById('netexp1');
+ config = JSON.parse(netexp.getAttribute('config'))
+ console.log(config)
+ config[name]=dataset
+ changeConfigStr(JSON.stringify(config))
+ }
+
function setNetwork(nw) {
const netexp = document.getElementById(nw);
diff --git a/src/index_static.html b/src/index_static.html
new file mode 100644
index 0000000000000000000000000000000000000000..a568ac0c4c47e945cae22217c7306486f7fdf6e4
--- /dev/null
+++ b/src/index_static.html
@@ -0,0 +1,211 @@
+<!doctype html>
+<html lang="en">
+<head>
+ <meta charset="utf-8">
+ <title>Network Expander</title>
+<!-- <base href="/">-->
+<!-- <meta name="viewport" content="width=device-width, initial-scale=1.0">-->
+<!-- <script type="text/javascript" src="https://unpkg.com/vis-network/standalone/umd/vis-network.min.js"></script>-->
+ <script src="https://cdn.drugst.one/latest/drugstone.js"></script>
+ <link rel="stylesheet" href="https://cdn.drugst.one/latest/styles.css">
+<!-- <link rel="stylesheet" type="text/css" href="./stylesheets/theme.css">-->
+</head>
+<body>
+
+<input type="checkbox" onclick=changeConfigStr('{"showOverview":'+this.checked+'}') checked /> Show overview<br>
+<input type="checkbox" onclick=changeConfigStr('{"showQuery":'+this.checked+'}') /> Show query<br>
+<!-- <input type="checkbox" onclick=changeConfigStr('{"showSidebar":'+this.checked+'}') checked /> Show sidebar<br> -->
+<input type="checkbox" onclick=changeConfigStr('{"showItemSelector":'+this.checked+'}') checked /> Show ItemSelector<br>
+<input type="checkbox" onclick=changeConfigStr('{"showSimpleAnalysis":'+this.checked+'}') /> Show SimpleAnalysis<br>
+<input type="checkbox" onclick=changeConfigStr('{"showAdvAnalysis":'+this.checked+'}') checked /> Show Advanced Analysis<br>
+<input type="checkbox" onclick=changeConfigStr('{"showTasks":'+this.checked+'}') checked /> Show Tasks<br>
+<input type="checkbox" onclick=changeConfigStr('{"showSelection":'+this.checked+'}') checked /> Show Selection<br>
+<input type="checkbox" onclick=changeConfigStr('{"showNetworkMenu":'+this.checked+'}') checked /> Show Footer<br>
+<input type="checkbox" onclick=changeConfigStr('{"showLegend":'+this.checked+'}') checked /> Show Legend<br>
+<input type="checkbox" onclick=changeConfigStr('{"showNetworkMenuButtonScreenshot":'+this.checked+'}') checked /> Show Screenshot button<br>
+<input type="checkbox" onclick=changeConfigStr('{"showNetworkMenuButtonExportGraphml":'+this.checked+'}') checked /> Show Export As Graphml Button<br>
+
+
+<input id="new_color" type="text" /> <button onclick=changeColor(document.getElementById("new_color").value) >Set Color </button> <br>
+<button onclick=changeConfigStr('{"legendPos":"left"}') > Legend to Left </button> <br>
+<button onclick=changeConfigStr('{"legendPos":"right"}') > Legend to Right </button> <br>
+<button onclick=changeConfigStr('{"interactions":"omnipath"}') >Get Omnipath Interactions </button> <br>
+<button onclick=changeConfigStr('{"showSidebar":false}') > Hide sidebar</button><br>
+<button onclick=changeConfigStr('{"showSidebar":"left"}') > Mode sidebar to left</button><br>
+<button onclick=changeConfigStr('{"showSidebar":"right"}') > Move sidebar to right</button><br>
+<button onclick=changeConfigStr('{"showNetworkMenu":false}') > Hide networkMenu</button><br>
+<button onclick=changeConfigStr('{"showNetworkMenu":"left"}') > Mode networkMenu to left</button><br>
+<button onclick=changeConfigStr('{"showNetworkMenu":"right"}') > Move networkMenu to right</button><br>
+<button onclick="initTaskEventListener()">Init Task-Eventlistener</button> <br>
+
+<input id="taskID" type="text" /> <button onclick=loadTaskID(document.getElementById("taskID").value) class="button is-primary" >Load TaskID</button> <br>
+
+<br>
+<br>
+<b>Datasets</b>
+<div>
+ <i>Protein-Protein Interactions</i>
+ <select name="Protein-Protein Interactions" onchange="applyDataset()" id="ppi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="BioGRID">BioGRID</option>
+ <option value="IID">IID</option>
+ <option value="IntAct">IntAct</option>
+ <option value="STRING">STRING</option>
+ <option value="APID">APID</option>
+ </select>
+</div>
+<div>
+ <i>Drug-Protein Targets</i>
+ <select name="Drug-Protein Targets" onchange="applyDataset()" id="drpi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="DrugBank">DrugBank</option>
+ <option value="Drug Central">Drug Central</option>
+ <option value="ChEMBL">ChEMBL</option>
+ <option value="DGIdb">DGIdb</option>
+ </select>
+</div>
+
+<div>
+ <i>Drug-Disorder Indications</i>
+ <select name="Drug-Disorder Indications" onchange="applyDataset()" id="drdi-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="CTD">CTD</option>
+ <option value="Drug Central">Drug Central</option>
+ <option value="DrugBank">DrugBank</option>
+ </select>
+</div>
+<div>
+ <i>Protein-Disorder Associations</i>
+ <select name="Protein-Disorder Associations" onchange="applyDataset()" id="pdis-dataset">
+ <option value="NeDRex">NeDRex</option>
+ <option value="DisGeNET">CTD</option>
+ <option value="OMIM">Drug Central</option>
+ </select>
+</div>
+
+<!--<input type="checkbox" onclick=changeConfigStr('{"showSimpleAnalysis":'+this.checked+'}') checked /> Show SimpleAnalysis<br>-->
+
+<br>
+
+<button onclick="setNetwork('netexp1')">Add nodes</button>
+
+<div style="max-width: 80vw">
+
+ <drugst-one id="netexp1"
+ pluginId="2"
+ config='{"interactionDrugProtein":"NeDRex", "physicsOn":true, "showLeftSidebar": true, "showSimpleAnalysis":true, "nodeGroups":{"patient":{"type":"patient","color":"black","font":{"color":"#ffffff"},"groupName":"Patient","shape":"image","image":"https://static.thenounproject.com/png/22780-200.png"},"condition":{"type":"condition","color":"black","font":{"color":"black"},"groupName":"Condition","shape":"text"},"important":{"type":"gene","color":"#ff881f","font":{"color":"#000000"},"groupName":"Important Gene","shape":"star"},"gene":{"type":"gene","color":"#4da300","font":{"color":"#ffffff"},"groupName":"Gene","shape":"circle"},"foundDrug":{"type":"drug","color":{"border":"#F12590","background":"#F12590"},"font":{"color":"#f0f0f0"},"groupName":"Drug","shape":"diamond"}},"edgeGroups":{"genotype":{"color":"black","groupName":"Relevant Gene"},"has-condition":{"color":"#000000","groupName":"Has Condition","dashes":[2,2]},"default":{"color":"#000000","groupName":"default edge"},"ggi":{"color":"#000000","groupName":"Interaction","dashes":[3,2]}},"identifier":"symbol","title":"Breast cancer example network","nodeShadow":true,"edgeShadow":false,"autofillEdges":true,"showLegend":true}'
+ network='{"nodes":[{"id":"patient-1","group":"patient","x":592,"y":446},{"id":"patient-2","group":"patient","x":235,"y":87},{"id":"patient-3","group":"patient","x":105,"y":369},{"id":"ATM","label":"ATM","group":"gene","x":289,"y":242},{"id":"BARD1","label":"BARD1","group":"gene","x":44,"y":250},{"id":"BRCA1","label":"BRCA1","group":"gene","x":466,"y":576},{"id":"BRCA2","label":"BRCA2","group":"gene","x":507,"y":285},{"id":"BRIP1","label":"BRIP1","group":"gene","x":54,"y":474},{"id":"CHEK2","label":"CHEK2","group":"gene","x":216,"y":590},{"id":"CDH1","label":"CDH1","group":"gene","x":320,"y":-57},{"id":"NF1","label":"NF1","group":"gene","x":481,"y":111},{"id":"NBN","label":"NBN","group":"gene","x":-57,"y":314},{"id":"PALB2","label":"PALB2","group":"gene","x":450,"y":190},{"id":"PTEN","label":"PTEN","group":"important","x":305,"y":494},{"id":"RAD51C","label":"RAD51C","group":"gene","x":182,"y":-90},{"id":"RAD51D","label":"RAD51D","group":"gene","x":368,"y":73},{"id":"STK11","label":"STK11","group":"gene","x":686,"y":330},{"id":"TP53","label":"TP53","group":"important","x":333,"y":316},{"id":"subtype-1","label":"Subtype 1","group":"condition","x":556,"y":171},{"id":"subtype-2","label":"Subtype 2","group":"condition","x":-87,"y":221}],"edges":[]}'>
+ </drugst-one>
+</div>
+
+<!--<div >-->
+
+<!-- <network-expander id="netexp2"-->
+<!-- pluginId="2"-->
+<!-- config='{}' network='{"nodes":[], "edges":[]}'></network-expander>-->
+<!--</div>-->
+
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+<br>
+
+
+<script>
+
+
+ function changeConfig() {
+ const netexp = document.getElementById('netexp1');
+ netexp.setAttribute('config', '{"showLeftSidebar": false}');
+ }
+
+ function changeConfigStr(config) {
+ console.log(config);
+ const netexp = document.getElementById('netexp1');
+ netexp.setAttribute('config', config);
+ }
+
+ function initTaskEventListener(){
+ document.getElementsByTagName("network-expander")[0].addEventListener("taskEvent",(event)=>{console.log(event.detail)})
+ }
+
+ function applyDataset(){
+ let ppi = document.getElementById('ppi-dataset')
+ setDataset('interactionProteinProtein',ppi.options[ppi.selectedIndex].value)
+ let drpi = document.getElementById('drpi-dataset')
+ setDataset('interactionDrugProtein', drpi.options[drpi.selectedIndex].value)
+ let drdi = document.getElementById('drdi-dataset')
+ setDataset('indicationDrugDisorder', drdi.options[drdi.selectedIndex].value)
+ let pdis = document.getElementById('pdis-dataset')
+ setDataset('associatedProteinDisorder', pdis.options[pdis.selectedIndex].value)
+
+
+ }
+
+ function setDataset(name, dataset){
+ // console.log(event)
+ console.log("Dataset "+name+" -> "+dataset)
+ const netexp = document.getElementById('netexp1');
+ config = JSON.parse(netexp.getAttribute('config'))
+ console.log(config)
+ config[name]=dataset
+ changeConfigStr(JSON.stringify(config))
+ }
+
+
+ function setNetwork(nw) {
+ const netexp = document.getElementById(nw);
+
+ netexp.setAttribute('network', JSON.stringify({
+ nodes: [
+ {
+ name: "ENSG00000171862",
+ id: "ENSG00000171862",
+ group: "genes"
+ }
+ ],
+ edges: [
+
+ ]
+ }));
+ }
+
+ function changeColor(hexacode) {
+ console.log(hexacode)
+ const elements_background_color = document.getElementsByClassName('is-primary');
+ for(var i = 0; i < elements_background_color.length; i++){
+ elements_background_color[i].setAttribute('style', `background-color: ${hexacode} !important; color: white !important; border-color: ${hexacode} !important`);
+ }
+ const elements_text = document.getElementsByClassName('text-primary');
+ for(var i = 0; i < elements_text.length; i++){
+ elements_text[i].setAttribute('style', `color: ${hexacode} !important`);
+ }
+ }
+
+ function loadTaskID(token){
+ console.log("Trying to load "+token)
+ const netexp = document.getElementById('netexp1');
+ netexp.setAttribute('task-id', token);
+
+ }
+
+</script>
+</body>
+</html>