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launch-analysis.component.html

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    launch-analysis.component.html 8.83 KiB
    <div class="modal" [class.is-active]="show">
      <div class="modal-background"></div>
      <div class="modal-card">
        <header class="modal-card-head">
          <p class="modal-card-title" *ngIf="target === 'drug'">
            <span class="icon"><i class="fa fa-capsules"></i></span>
            Find Drugs
          </p>
          <p class="modal-card-title" *ngIf="target === 'drug-target'">
            <span class="icon"><i class="fa fa-crosshairs"></i></span>
            Find Drug Targets
          </p>
          <button (click)="close()" class="delete" aria-label="close"></button>
        </header>
        <section class="modal-card-body">
          <div *ngIf="target === 'drug' && hasBaits">
            <div class="notification is-warning warning">
              You have selected <i class="fa fa-virus"></i> viral proteins.
              When finding drugs, make sure you have selected <i class="fa fa-dna"></i> host proteins only.
            </div>
          </div>
    
          <div *ngIf="!analysis.canLaunchTask()">
            <div class="notification is-warning warning">
              You can only run {{maxTasks}} tasks at once. Please wait for one of them to finish or delete it from the task
              list.
            </div>
          </div>
    
          <div *ngIf="algorithm === 'keypathwayminer' && hasBaits">
            <div class="notification is-warning warning">
              You have selected <i class="fa fa-virus"></i> viral proteins.
              If you want to use KeyPathwayMiner, please remove them because it cannot process them.
            </div>
          </div>
    
          <div class="tabs is-toggle is-small is-fullwidth is-rounded has-tooltip">
            <ul>
              <li [class.is-active]="algorithm === algo.slug" *ngFor="let algo of algorithms">
                <a (click)="algorithm = algo.slug" class="is-boxed is-medium">{{algo.name}}</a>
              </li>
            </ul>
          </div>
    
          <div *ngIf="algorithm==='trustrank'">
            <p class="help info">
              <span class="icon"><i class="fa fa-info"></i></span>
              <a href="https://en.wikipedia.org/wiki/TrustRank" target="_blank">TrustRank</a>
              is a node centrality measure that ranks nodes in a network based on how well they are connected to a
              (trusted) set of seed nodes (Gyöngyi, Garcia-Molina, and Pedersen 2004).
            </p>
            <div class="field" *ngIf="target === 'drug'">
              <label class="label">Indirect Drugs</label>
              <app-toggle textOn="Include" textOff="Ignore" tooltipOn="Include indirect drugs."
                          tooltipOff="Exclude indirect drugs from the result."
                          [(value)]="trustrankIncludeIndirectDrugs"></app-toggle>
            </div>
            <div class="field" *ngIf="target === 'drug'">
              <label class="label">Non-approved Drugs</label>
              <app-toggle textOn="Include" textOff="Ignore" tooltipOn="Include non-approved drugs."
                          tooltipOff="Exclude non-approved drugs from the result."
                          [(value)]="trustrankIncludeNonApprovedDrugs"></app-toggle>
            </div>
            <div class="field">
              <label class="label" for="trustrank-df">Damping Factor</label>
              <div class="control">
                <input [(ngModel)]="trustrankDampingFactor" id="trustrank-df" class="input" type="number"
                       placeholder="Damping factor"
                       min="0" max="1"
                       required>
              </div>
            </div>
            <div class="field">
              <label class="label" for="trustrank-rs">Result Size</label>
              <div class="control">
                <input [(ngModel)]="trustrankResultSize" id="trustrank-rs" class="input" type="number"
                       placeholder="Result size" required>
              </div>
            </div>
          </div>
    
          <div *ngIf="algorithm==='closeness'">
            <p class="help info"> <span class="icon"><i class="fa fa-info"></i></span>
              <a href="https://en.wikipedia.org/wiki/Closeness_centrality" target="_blank">Closeness Centrality</a>
              is a node centrality measure that ranks the nodes in a network based on the lengths of their shortest paths
              to all other nodes in the network (Kaczprowski, Doncheva, and Albrecht 2013).
            </p>
            <div class="field" *ngIf="target === 'drug'">
              <label class="label">Indirect Drugs</label>
              <app-toggle textOn="Include" textOff="Ignore" tooltipOn="Include indirect drugs."
                          tooltipOff="Exclude indirect drugs from the result."
                          [(value)]="closenessIncludeIndirectDrugs"></app-toggle>
            </div>
            <div class="field" *ngIf="target === 'drug'">
              <label class="label">Non-approved Drugs</label>
              <app-toggle textOn="Include" textOff="Ignore" tooltipOn="Include non-approved drugs."
                          tooltipOff="Exclude non-approved drugs from the result."
                          [(value)]="closenessIncludeNonApprovedDrugs"></app-toggle>
            </div>
            <div class="field">
              <label class="label" for="closeness-rs">Result Size</label>
              <div class="control">
                <input [(ngModel)]="closenessResultSize" id="closeness-rs" class="input" type="number"
                       placeholder="Result size" required>
              </div>
            </div>
          </div>
    
          <div *ngIf="algorithm==='degree'">
            <p class="help info"> <span class="icon"><i class="fa fa-info"></i></span>
              <a href="https://en.wikipedia.org/wiki/Centrality#Degree_centrality" target="_blank">Degree Centrality</a>
              assigns an importance score based simply on the number of links held by each node.
            </p>
            <div class="field" *ngIf="target === 'drug'">
              <label class="label">Non-approved Drugs</label>
              <app-toggle textOn="Include" textOff="Ignore" tooltipOn="Include non-approved drugs."
                          tooltipOff="Exclude non-approved drugs from the result."
                          [(value)]="degreeIncludeNonApprovedDrugs"></app-toggle>
            </div>
            <div class="field">
              <label class="label" for="degree-rs">Result Size</label>
              <div class="control">
                <input [(ngModel)]="degreeResultSize" id="degree-rs" class="input" type="number"
                       placeholder="Result size" required>
              </div>
            </div>
          </div>
    
          <div *ngIf="algorithm==='keypathwayminer'">
            <p class="help info"> <span class="icon"><i class="fa fa-info"></i></span>
              <a href="https://keypathwayminer.compbio.sdu.dk/keypathwayminer/">KeyPathwayMiner</a>
              is a network enrichment tool that identifies condition-specific sub-networks (key pathways)
              (Alcaraz et al. 2016).
            </p>
            <div class="field">
              <label class="label" for="keypathwayminer-k">K</label>
              <div class="control">
                <div class="select">
                  <select id="keypathwayminer-k" [(ngModel)]="keypathwayminerK">
                    <option [ngValue]="1">1</option>
                    <option [ngValue]="2">2</option>
                    <option [ngValue]="3">3</option>
                    <option [ngValue]="4">4</option>
                    <option [ngValue]="5">5</option>
                  </select>
                </div>
              </div>
            </div>
          </div>
    
          <div *ngIf="algorithm==='multisteiner'">
            <p class="help info"> <span class="icon"><i class="fa fa-info"></i></span>
              The <a href="https://en.wikipedia.org/wiki/Steiner_tree_problem">Steiner tree</a>
              problem is a classical combinatorial optimization problem. It asks to find a sub-graph
              of minimum size connecting a given set of seed nodes.
            </p>
            <div class="field">
              <label class="label" for="multisteiner-numtrees">Number of Steiner trees to return</label>
              <div class="control">
                <div class="select">
                  <select id="multisteiner-numtrees" [(ngModel)]="multisteinerNumTrees">
                    <option [ngValue]="1">1</option>
                    <option [ngValue]="2">2</option>
                    <option [ngValue]="3">3</option>
                    <option [ngValue]="5">5</option>
                    <option [ngValue]="10">10</option>
                    <option [ngValue]="15">15</option>
                    <option [ngValue]="20">20</option>
                    <option [ngValue]="25">25</option>
                  </select>
                </div>
              </div>
            </div>
          </div>
        </section>
    
        <footer class="modal-card-foot">
          <button (click)="startTask(); close()" class="button is-success is-rounded has-tooltip"
                  data-tooltip="Run the analysis."
                  [disabled]="(target === 'drug' && hasBaits) || !analysis.canLaunchTask() || (algorithm === 'keypathwayminer' && hasBaits)">
            <span class="icon">
              <i class="fa fa-rocket"></i>
            </span>
            <span>
              Launch
            </span>
          </button>
          <button (click)="close()" class="button is-rounded has-tooltip" data-tooltip="Close the current window.">Close</button>
        </footer>
      </div>
    </div>