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Commit 340e9c08 authored by AndiMajore's avatar AndiMajore
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added config for activating adjacent drugs and disorders

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src/app/components/analysis-panel/analysis-panel.component.ts
+ 1
− 0
View file @ 340e9c08
...@@ -204,6 +204,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit ...@@ -204,6 +204,7 @@ export class AnalysisPanelComponent implements OnInit, OnChanges, AfterViewInit
if (!this.drugstoneConfig.config.physicsOn) { if (!this.drugstoneConfig.config.physicsOn) {
this.networkHandler.activeNetwork.updatePhysicsEnabled(false); this.networkHandler.activeNetwork.updatePhysicsEnabled(false);
} }
this.networkHandler.updateAdjacentNodes();
}); });
this.tableDrugs = nodes.filter(e => e.drugstoneId && e.drugstoneType === 'drug'); this.tableDrugs = nodes.filter(e => e.drugstoneId && e.drugstoneType === 'drug');
this.tableDrugs.forEach((r) => { this.tableDrugs.forEach((r) => {
......
src/app/components/network/network.component.ts
+ 91
− 76
View file @ 340e9c08
...@@ -21,7 +21,7 @@ import {NetworkSettings} from 'src/app/network-settings'; ...@@ -21,7 +21,7 @@ import {NetworkSettings} from 'src/app/network-settings';
import {pieChartContextRenderer} from 'src/app/utils'; import {pieChartContextRenderer} from 'src/app/utils';
import {NetworkHandlerService} from 'src/app/services/network-handler/network-handler.service'; import {NetworkHandlerService} from 'src/app/services/network-handler/network-handler.service';
import {LegendService} from 'src/app/services/legend-service/legend-service.service'; import {LegendService} from 'src/app/services/legend-service/legend-service.service';
import { LoadingScreenService } from 'src/app/services/loading-screen/loading-screen.service'; import {LoadingScreenService} from 'src/app/services/loading-screen/loading-screen.service';
@Component({ @Component({
...@@ -81,7 +81,7 @@ export class NetworkComponent implements OnInit { ...@@ -81,7 +81,7 @@ export class NetworkComponent implements OnInit {
public nodeRenderer = null; public nodeRenderer = null;
public loading = false public loading = false;
constructor( constructor(
public configService: DrugstoneConfigService, public configService: DrugstoneConfigService,
...@@ -91,8 +91,8 @@ export class NetworkComponent implements OnInit { ...@@ -91,8 +91,8 @@ export class NetworkComponent implements OnInit {
public drugstoneConfig: DrugstoneConfigService, public drugstoneConfig: DrugstoneConfigService,
public netex: NetexControllerService, public netex: NetexControllerService,
public omnipath: OmnipathControllerService, public omnipath: OmnipathControllerService,
public loadingScreen: LoadingScreenService) public loadingScreen: LoadingScreenService) {
{} }
ngOnInit(): void { ngOnInit(): void {
this.networkHandler.networks[this.networkType] = this; this.networkHandler.networks[this.networkType] = this;
...@@ -116,15 +116,16 @@ export class NetworkComponent implements OnInit { ...@@ -116,15 +116,16 @@ export class NetworkComponent implements OnInit {
updateQueryItems() { updateQueryItems() {
this.queryItems = []; this.queryItems = [];
if (this.currentViewNodes) if (this.currentViewNodes) {
this.currentViewNodes.forEach((protein) => { this.currentViewNodes.forEach((protein) => {
this.queryItems.push(getWrapperFromNode(protein)); this.queryItems.push(getWrapperFromNode(protein));
}); });
}
} }
public saveAddNodes(nodeList: Node[]) { public saveAddNodes(nodeList: Node[]) {
const existing = this.nodeData.nodes.get().map(n => n.id); const existing = this.nodeData.nodes.get().map(n => n.id);
const toAdd = nodeList.filter(n => existing.indexOf(n.id) === -1) const toAdd = nodeList.filter(n => existing.indexOf(n.id) === -1);
this.nodeData.nodes.add(toAdd); this.nodeData.nodes.add(toAdd);
} }
...@@ -132,31 +133,33 @@ export class NetworkComponent implements OnInit { ...@@ -132,31 +133,33 @@ export class NetworkComponent implements OnInit {
this.loadingScreen.stateUpdate(true); this.loadingScreen.stateUpdate(true);
this.adjacentDisordersProtein = bool; this.adjacentDisordersProtein = bool;
if (this.adjacentDisordersProtein) { if (this.adjacentDisordersProtein) {
this.legendService.add_to_context('adjacentDisorders') this.legendService.add_to_context('adjacentDisorders');
this.netex.adjacentDisorders(this.nodeData.nodes.get(), 'proteins', this.drugstoneConfig.config.associatedProteinDisorder, this.drugstoneConfig.config.licensedDatasets).subscribe(response => { this.netex.adjacentDisorders(this.nodeData.nodes.get(), 'proteins', this.drugstoneConfig.config.associatedProteinDisorder, this.drugstoneConfig.config.licensedDatasets).subscribe(response => {
const proteinMap = this.getProteinMap() const proteinMap = this.getProteinMap();
const addedEdge = {} const addedEdge = {};
for (const interaction of response.edges) { for (const interaction of response.edges) {
const edge = mapCustomEdge({from: interaction.protein, to: interaction.disorder}, this.drugstoneConfig.config) const edge = mapCustomEdge({from: interaction.protein, to: interaction.disorder}, this.drugstoneConfig.config);
if (proteinMap[edge.from]) { if (proteinMap[edge.from]) {
proteinMap[edge.from].forEach(from => { proteinMap[edge.from].forEach(from => {
if (addedEdge[from] && addedEdge[from].indexOf(edge.to) !== -1) if (addedEdge[from] && addedEdge[from].indexOf(edge.to) !== -1) {
return return;
const e = JSON.parse(JSON.stringify(edge)) }
e.from = from const e = JSON.parse(JSON.stringify(edge));
e.to = edge.to e.from = from;
e.to = edge.to;
this.adjacentProteinDisorderEdgesList.push(e); this.adjacentProteinDisorderEdgesList.push(e);
if (!addedEdge[from]) if (!addedEdge[from]) {
addedEdge[from] = [edge.to] addedEdge[from] = [edge.to];
else } else {
addedEdge[from].push(edge.to) addedEdge[from].push(edge.to);
}) }
});
} }
} }
for (const disorder of response.disorders) { for (const disorder of response.disorders) {
disorder.group = 'defaultDisorder'; disorder.group = 'defaultDisorder';
disorder.id = disorder.drugstoneId; disorder.id = disorder.drugstoneId;
this.adjacentProteinDisorderList.push(mapCustomNode(disorder, this.drugstoneConfig.currentConfig())) this.adjacentProteinDisorderList.push(mapCustomNode(disorder, this.drugstoneConfig.currentConfig()));
} }
this.saveAddNodes(this.adjacentProteinDisorderList); this.saveAddNodes(this.adjacentProteinDisorderList);
this.nodeData.edges.add(this.adjacentProteinDisorderEdgesList); this.nodeData.edges.add(this.adjacentProteinDisorderEdgesList);
...@@ -197,8 +200,9 @@ export class NetworkComponent implements OnInit { ...@@ -197,8 +200,9 @@ export class NetworkComponent implements OnInit {
this.loadingScreen.stateUpdate(false); this.loadingScreen.stateUpdate(false);
}); });
} else { } else {
if (!this.adjacentDisordersProtein) if (!this.adjacentDisordersProtein) {
this.legendService.remove_from_context('adjacentDisorders'); this.legendService.remove_from_context('adjacentDisorders');
}
this.saveRemoveDisorders(this.adjacentDrugDisorderList); this.saveRemoveDisorders(this.adjacentDrugDisorderList);
this.nodeData.edges.remove(this.adjacentDrugDisorderEdgesList); this.nodeData.edges.remove(this.adjacentDrugDisorderEdgesList);
this.adjacentDrugDisorderList = []; this.adjacentDrugDisorderList = [];
...@@ -209,68 +213,73 @@ export class NetworkComponent implements OnInit { ...@@ -209,68 +213,73 @@ export class NetworkComponent implements OnInit {
} }
public getProteinMap() { public getProteinMap() {
const proteinMap = {} const proteinMap = {};
this.nodeData.nodes.get().forEach(n => { this.nodeData.nodes.get().forEach(n => {
if (n.drugstoneType === 'protein') { if (n.drugstoneType === 'protein') {
n.drugstoneId.forEach(id => { n.drugstoneId.forEach(id => {
if (typeof id === 'string') { if (typeof id === 'string') {
if (proteinMap[id]) if (proteinMap[id]) {
proteinMap[id].push(n.id) proteinMap[id].push(n.id);
else } else {
proteinMap[id] = [n.id]; proteinMap[id] = [n.id];
}
} else { } else {
n.id.forEach(single_id => { n.id.forEach(single_id => {
if (proteinMap[single_id]) if (proteinMap[single_id]) {
proteinMap[single_id].push(n.id) proteinMap[single_id].push(n.id);
else } else {
proteinMap[single_id] = [n.id]; proteinMap[single_id] = [n.id];
}) }
});
} }
}); });
} }
}); });
return proteinMap return proteinMap;
} }
public updateAdjacentDrugs(bool: boolean) { public updateAdjacentDrugs(bool: boolean) {
this.loadingScreen.stateUpdate(true); this.loadingScreen.stateUpdate(true);
this.adjacentDrugs = bool; this.adjacentDrugs = bool;
if (this.adjacentDrugs) { if (this.adjacentDrugs) {
this.legendService.add_to_context("adjacentDrugs") this.legendService.add_to_context('adjacentDrugs');
const addedEdge = {} const addedEdge = {};
const proteinMap = this.getProteinMap() const proteinMap = this.getProteinMap();
this.netex.adjacentDrugs(this.drugstoneConfig.config.interactionDrugProtein, this.drugstoneConfig.config.licensedDatasets, this.nodeData.nodes.get()).subscribe(response => { this.netex.adjacentDrugs(this.drugstoneConfig.config.interactionDrugProtein, this.drugstoneConfig.config.licensedDatasets, this.nodeData.nodes.get()).subscribe(response => {
const existingDrugIDs = this.nodeData.nodes.get().filter(n => n.drugstoneId && n.drugstoneType === 'drug').map(n => n.drugstoneId); const existingDrugIDs = this.nodeData.nodes.get().filter(n => n.drugstoneId && n.drugstoneType === 'drug').map(n => n.drugstoneId);
for (const interaction of response.pdis) { for (const interaction of response.pdis) {
const edge = mapCustomEdge({from: interaction.protein, to: interaction.drug}, this.drugstoneConfig.currentConfig()) const edge = mapCustomEdge({from: interaction.protein, to: interaction.drug}, this.drugstoneConfig.currentConfig());
if (proteinMap[edge.from]) { if (proteinMap[edge.from]) {
proteinMap[edge.from].forEach(from => { proteinMap[edge.from].forEach(from => {
if (addedEdge[from] && addedEdge[from].indexOf(edge.to) !== -1) if (addedEdge[from] && addedEdge[from].indexOf(edge.to) !== -1) {
return return;
const e = JSON.parse(JSON.stringify(edge)) }
e.from = from const e = JSON.parse(JSON.stringify(edge));
e.to = edge.to e.from = from;
e.to = edge.to;
this.adjacentDrugEdgesList.push(e); this.adjacentDrugEdgesList.push(e);
if (!addedEdge[from]) if (!addedEdge[from]) {
addedEdge[from] = [edge.to] addedEdge[from] = [edge.to];
else } else {
addedEdge[from].push(edge.to) addedEdge[from].push(edge.to);
}) }
});
} }
} }
for (const drug of response.drugs) { for (const drug of response.drugs) {
drug.group = 'foundDrug'; drug.group = 'foundDrug';
drug.id = getDrugNodeId(drug); drug.id = getDrugNodeId(drug);
if (existingDrugIDs.indexOf(drug.drugstoneId) === -1) { if (!existingDrugIDs.includes(drug.drugstoneId)) {
this.adjacentDrugList.push(mapCustomNode(drug, this.drugstoneConfig.currentConfig())) existingDrugIDs.push(drug.drugstoneId);
this.adjacentDrugList.push(mapCustomNode(drug, this.drugstoneConfig.currentConfig()));
} }
} }
this.nodeData.nodes.add(this.adjacentDrugList); this.nodeData.nodes.add(this.adjacentDrugList);
this.nodeData.edges.add(this.adjacentDrugEdgesList); this.nodeData.edges.add(this.adjacentDrugEdgesList);
this.updateQueryItems(); this.updateQueryItems();
this.loadingScreen.stateUpdate(false); this.loadingScreen.stateUpdate(false);
}) });
} else { } else {
// remove adjacent drugs, make sure that also drug associated disorders are removed // remove adjacent drugs, make sure that also drug associated disorders are removed
if (this.adjacentDisordersDrug) { if (this.adjacentDisordersDrug) {
...@@ -290,13 +299,13 @@ export class NetworkComponent implements OnInit { ...@@ -290,13 +299,13 @@ export class NetworkComponent implements OnInit {
} }
public saveRemoveDisorders(nodeList: Node[]) { public saveRemoveDisorders(nodeList: Node[]) {
const other = this.adjacentDrugDisorderList === nodeList ? this.adjacentProteinDisorderList : this.adjacentDrugDisorderList const other = this.adjacentDrugDisorderList === nodeList ? this.adjacentProteinDisorderList : this.adjacentDrugDisorderList;
if (other == null) if (other == null) {
this.nodeData.nodes.remove(nodeList); this.nodeData.nodes.remove(nodeList);
else { } else {
const otherIds = other.map(d => d.id); const otherIds = other.map(d => d.id);
const rest = nodeList.filter(d => otherIds.indexOf(d.id) === -1) const rest = nodeList.filter(d => otherIds.indexOf(d.id) === -1);
this.nodeData.nodes.remove(rest) this.nodeData.nodes.remove(rest);
} }
} }
...@@ -367,7 +376,7 @@ export class NetworkComponent implements OnInit { ...@@ -367,7 +376,7 @@ export class NetworkComponent implements OnInit {
this.nodeRenderer = null; this.nodeRenderer = null;
const updatedNodes = []; const updatedNodes = [];
// for (const item of this.proteins) { // for (const item of this.proteins) {
const proteins = this.nodeData.nodes.get().filter(n => n.drugstoneId && n.drugstoneType === 'protein') const proteins = this.nodeData.nodes.get().filter(n => n.drugstoneId && n.drugstoneType === 'protein');
for (const node of proteins) { for (const node of proteins) {
const pos = this.networkInternal.getPositions([node.id]); const pos = this.networkInternal.getPositions([node.id]);
node.x = pos[node.id].x; node.x = pos[node.id].x;
...@@ -421,31 +430,33 @@ export class NetworkComponent implements OnInit { ...@@ -421,31 +430,33 @@ export class NetworkComponent implements OnInit {
const updatedNodes = []; const updatedNodes = [];
this.nodeRenderer = pieChartContextRenderer; this.nodeRenderer = pieChartContextRenderer;
// mapping from netex IDs to network IDs, TODO check if this step is necessary // mapping from netex IDs to network IDs, TODO check if this step is necessary
const networkIdMapping = {} const networkIdMapping = {};
this.nodeData.nodes.get().forEach(element => { this.nodeData.nodes.get().forEach(element => {
if (element.drugstoneType === 'protein') { if (element.drugstoneType === 'protein') {
element.drugstoneId.forEach(id => { element.drugstoneId.forEach(id => {
if (networkIdMapping[id]) if (networkIdMapping[id]) {
networkIdMapping[id].push(element.id); networkIdMapping[id].push(element.id);
else } else {
networkIdMapping[id] = [element.id] networkIdMapping[id] = [element.id];
}
}); });
} }
}); });
const maxExpr = Math.max(...Object.values(this.expressionMap)); const maxExpr = Math.max(...Object.values(this.expressionMap));
const exprMap = {} const exprMap = {};
for (const [drugstoneId, expressionlvl] of Object.entries(this.expressionMap)) { for (const [drugstoneId, expressionlvl] of Object.entries(this.expressionMap)) {
networkIdMapping[drugstoneId].forEach(networkId => { networkIdMapping[drugstoneId].forEach(networkId => {
if (!exprMap[networkId]) if (!exprMap[networkId]) {
exprMap[networkId] = [expressionlvl] exprMap[networkId] = [expressionlvl];
else } else {
exprMap[networkId].push(expressionlvl) exprMap[networkId].push(expressionlvl);
}) }
});
} }
this.expressionMap = {} this.expressionMap = {};
Object.keys(exprMap).forEach(networkId => { Object.keys(exprMap).forEach(networkId => {
const expressionlvl = exprMap[networkId] ? exprMap[networkId].reduce((a, b) => a + b) / exprMap[networkId].length : null; const expressionlvl = exprMap[networkId] ? exprMap[networkId].reduce((a, b) => a + b) / exprMap[networkId].length : null;
this.expressionMap[networkId] = expressionlvl this.expressionMap[networkId] = expressionlvl;
const node = this.nodeData.nodes.get(networkId); const node = this.nodeData.nodes.get(networkId);
if (node === null) { if (node === null) {
return; return;
...@@ -468,20 +479,23 @@ export class NetworkComponent implements OnInit { ...@@ -468,20 +479,23 @@ export class NetworkComponent implements OnInit {
node.shape = 'custom'; node.shape = 'custom';
node.ctxRenderer = pieChartContextRenderer; node.ctxRenderer = pieChartContextRenderer;
updatedNodes.push(node); updatedNodes.push(node);
}) });
this.nodeData.nodes.update(updatedNodes); this.nodeData.nodes.update(updatedNodes);
this.loadingScreen.stateUpdate(false); this.loadingScreen.stateUpdate(false);
} }
) );
} }
this.currentViewSelectedTissue = this.selectedTissue; this.currentViewSelectedTissue = this.selectedTissue;
} }
public hasDrugsLoaded(): boolean { public hasDrugsLoaded(): boolean {
if (this.nodeData && this.nodeData.nodes) if (this.nodeData && this.nodeData.nodes) {
for (const node of this.nodeData.nodes.get()) for (const node of this.nodeData.nodes.get()) {
if (node.drugstoneType && node.drugstoneId === 'drug') if (node.drugstoneType && node.drugstoneId === 'drug') {
return true; return true;
}
}
}
return false; return false;
} }
...@@ -497,10 +511,11 @@ export class NetworkComponent implements OnInit { ...@@ -497,10 +511,11 @@ export class NetworkComponent implements OnInit {
this.loadingScreen.stateUpdate(true); this.loadingScreen.stateUpdate(true);
this.highlightSeeds = bool; this.highlightSeeds = bool;
const updatedNodes = []; const updatedNodes = [];
if (this.highlightSeeds) if (this.highlightSeeds) {
this.legendService.add_to_context('seeds') this.legendService.add_to_context('seeds');
else } else {
this.legendService.remove_from_context('seeds') this.legendService.remove_from_context('seeds');
}
for (const node of this.nodeData.nodes.get().filter(n => n.drugstoneType === 'protein')) { for (const node of this.nodeData.nodes.get().filter(n => n.drugstoneType === 'protein')) {
if (node.drugstoneId === undefined) { if (node.drugstoneId === undefined) {
// nodes that are not mapped to backend remain untouched // nodes that are not mapped to backend remain untouched
...@@ -510,7 +525,7 @@ export class NetworkComponent implements OnInit { ...@@ -510,7 +525,7 @@ export class NetworkComponent implements OnInit {
if (!node) { if (!node) {
continue; continue;
} }
console.log(node) console.log(node);
const pos = this.networkHandler.activeNetwork.networkInternal.getPositions([node.id]); const pos = this.networkHandler.activeNetwork.networkInternal.getPositions([node.id]);
node.x = pos[node.id].x; node.x = pos[node.id].x;
node.y = pos[node.id].y; node.y = pos[node.id].y;
......
src/app/config.ts
+ 6
− 1
View file @ 340e9c08
...@@ -60,11 +60,14 @@ export interface IConfig { ...@@ -60,11 +60,14 @@ export interface IConfig {
showNetworkMenuButtonScreenshot: boolean; showNetworkMenuButtonScreenshot: boolean;
showNetworkMenuButtonExportGraphml: boolean; showNetworkMenuButtonExportGraphml: boolean;
showNetworkMenuButtonAdjacentDrugs: boolean; showNetworkMenuButtonAdjacentDrugs: boolean;
activateNetworkMenuButtonAdjacentDrugs: boolean;
showNetworkMenuButtonCenter: boolean; showNetworkMenuButtonCenter: boolean;
showConnectGenes: boolean; showConnectGenes: boolean;
networkMenuButtonAdjacentDrugsLabel: string; networkMenuButtonAdjacentDrugsLabel: string;
showNetworkMenuButtonAdjacentDisordersProteins: boolean; showNetworkMenuButtonAdjacentDisordersProteins: boolean;
activateNetworkMenuButtonAdjacentDisorders: boolean;
networkMenuButtonAdjacentDisordersProteinsLabel: string; networkMenuButtonAdjacentDisordersProteinsLabel: string;
activateNetworkMenuButtonAdjacentDisorderDrugs: boolean;
showNetworkMenuButtonAdjacentDisordersDrugs: boolean; showNetworkMenuButtonAdjacentDisordersDrugs: boolean;
networkMenuButtonAdjacentDisordersDrugsLabel: string; networkMenuButtonAdjacentDisordersDrugsLabel: string;
showNetworkMenuButtonAnimation: boolean; showNetworkMenuButtonAnimation: boolean;
...@@ -155,10 +158,12 @@ export const defaultConfig: IConfig = { ...@@ -155,10 +158,12 @@ export const defaultConfig: IConfig = {
showNetworkMenuButtonScreenshot: true, showNetworkMenuButtonScreenshot: true,
showNetworkMenuButtonExportGraphml: true, showNetworkMenuButtonExportGraphml: true,
showNetworkMenuButtonAdjacentDrugs: true, showNetworkMenuButtonAdjacentDrugs: true,
activateNetworkMenuButtonAdjacentDrugs: false,
showNetworkMenuButtonCenter: true, showNetworkMenuButtonCenter: true,
showNetworkMenuButtonAnimation: true, showNetworkMenuButtonAnimation: true,
activateNetworkMenuButtonAdjacentDisorders: false,
showNetworkMenuButtonAdjacentDisordersProteins: true, showNetworkMenuButtonAdjacentDisordersProteins: true,
activateNetworkMenuButtonAdjacentDisorderDrugs: false,
showNetworkMenuButtonAdjacentDisordersDrugs: true, showNetworkMenuButtonAdjacentDisordersDrugs: true,
showConnectGenes: true, showConnectGenes: true,
networkMenuButtonAdjacentDrugsLabel: 'Drugs', networkMenuButtonAdjacentDrugsLabel: 'Drugs',
......
src/app/pages/explorer-page/explorer-page.component.ts
+ 1
− 0
View file @ 340e9c08
...@@ -228,6 +228,7 @@ export class ExplorerPageComponent implements OnInit, AfterViewInit { ...@@ -228,6 +228,7 @@ export class ExplorerPageComponent implements OnInit, AfterViewInit {
if (this.drugstoneConfig.config.physicsOn) { if (this.drugstoneConfig.config.physicsOn) {
this.networkHandler.activeNetwork.updatePhysicsEnabled(true); this.networkHandler.activeNetwork.updatePhysicsEnabled(true);
} }
this.networkHandler.updateAdjacentNodes();
}); });
} }
} }
......
src/app/services/network-handler/network-handler.service.ts
+ 17
− 2
View file @ 340e9c08
...@@ -6,8 +6,8 @@ import {AnalysisService} from '../analysis/analysis.service'; ...@@ -6,8 +6,8 @@ import {AnalysisService} from '../analysis/analysis.service';
import {DrugstoneConfigService} from '../drugstone-config/drugstone-config.service'; import {DrugstoneConfigService} from '../drugstone-config/drugstone-config.service';
import {NetexControllerService} from '../netex-controller/netex-controller.service'; import {NetexControllerService} from '../netex-controller/netex-controller.service';
import {OmnipathControllerService} from '../omnipath-controller/omnipath-controller.service'; import {OmnipathControllerService} from '../omnipath-controller/omnipath-controller.service';
import {LegendService} from "../legend-service/legend-service.service"; import {LegendService} from '../legend-service/legend-service.service';
import { LoadingScreenService } from '../loading-screen/loading-screen.service'; import {LoadingScreenService} from '../loading-screen/loading-screen.service';
@Injectable({ @Injectable({
providedIn: 'root' providedIn: 'root'
...@@ -34,4 +34,19 @@ export class NetworkHandlerService { ...@@ -34,4 +34,19 @@ export class NetworkHandlerService {
get getChange$() { get getChange$() {
return this.change.asObservable(); return this.change.asObservable();
} }
async updateAdjacentNodes() {
if (this.drugstoneConfig.config.activateNetworkMenuButtonAdjacentDrugs) {
this.activeNetwork.adjacentDrugs = true;
await this.activeNetwork.updateAdjacentDrugs(true);
}
if (this.drugstoneConfig.config.activateNetworkMenuButtonAdjacentDisorders) {
this.activeNetwork.adjacentDisordersProtein = true;
await this.activeNetwork.updateAdjacentProteinDisorders(true);
}
if (this.drugstoneConfig.config.activateNetworkMenuButtonAdjacentDisorderDrugs) {
this.activeNetwork.adjacentDisordersDrug = true;
await this.activeNetwork.updateAdjacentDrugDisorders(true);
}
}
} }
src/index.html
+ 1
− 1
View file @ 340e9c08
...@@ -97,7 +97,7 @@ ...@@ -97,7 +97,7 @@
<drugst-one id="tatata" <drugst-one id="tatata"
groups= '{ "nodeGroups" : { "selectedNode": { "borderWidth": 3,"borderWidthSelected": 4,"color": { "border": "#ffffff","highlight": {"border": "#ffffff"}},"font": { "color": "#F8981","size": 14 }},"Protein":{"shape":"circle","groupName":"Protein","type":"Protein","color":"#172b4d","font":{"color":"#ffffff"}}}}' groups= '{ "nodeGroups" : { "selectedNode": { "borderWidth": 3,"borderWidthSelected": 4,"color": { "border": "#ffffff","highlight": {"border": "#ffffff"}},"font": { "color": "#F8981","size": 14 }},"Protein":{"shape":"circle","groupName":"Protein","type":"Protein","color":"#172b4d","font":{"color":"#ffffff"}}}}'
config='{ "identifier":"symbol","title":"ROBUST output network", "taskDrugName": "Drug Search", "showLegendNodes": true, "showLegendEdges": true, "showSidebar": "left", "showOverview": true, "legendPos": "left", "legendClass": "legend", "showQuery": true, "showItemSelector": true,"showSimpleAnalysis": false,"showAdvAnalysis": true,"showSelection": true,"showTasks": true,"showNetworkMenu": "right","showLegend": true,"showNetworkMenuButtonExpression": true, "showNetworkMenuButtonScreenshot": true,"showNetworkMenuButtonExportGraphml": true,"showNetworkMenuButtonAdjacentDrugs": true,"showNetworkMenuButtonCenter": true,"showConnectGenes": false,"networkMenuButtonAdjacentDrugsLabel": "Drugs","showNetworkMenuButtonAdjacentDisordersProteins": true,"networkMenuButtonAdjacentDisordersProteinsLabel": "Disorders (protein)","showNetworkMenuButtonAdjacentDisordersDrugs": true,"networkMenuButtonAdjacentDisordersDrugsLabel": "Disorders (drug)","showNetworkMenuButtonAnimation": true,"networkMenuButtonAnimationLabel": "Animation", "autofillEdges": true, "physicsOn": false,"useNedrexLicenced": true,"selfReferences": false, "interactionDrugProtein": "NeDRex", "indicationDrugDisorder": "NeDRex","nodeShadow": true,"edgeShadow": true, "algorithms": {"drug": ["trustrank", "closeness", "degree", "proximity"], "drug-target": ["trustrank", "multisteiner", "keypathwayminer", "degree", "closeness", "betweenness"]}, "associatedProteinDisorder": "NeDRex", "expandNetworkMenu": true}' config='{ "activateNetworkMenuButtonAdjacentDrugs": true,"activateNetworkMenuButtonAdjacentDisorders": true, "activateNetworkMenuButtonAdjacentDisorderDrugs": true, "identifier":"symbol","title":"ROBUST output network", "taskDrugName": "Drug Search", "showLegendNodes": true, "showLegendEdges": true, "showSidebar": "left", "showOverview": true, "legendPos": "left", "legendClass": "legend", "showQuery": true, "showItemSelector": true,"showSimpleAnalysis": false,"showAdvAnalysis": true,"showSelection": true,"showTasks": true,"showNetworkMenu": "right","showLegend": true,"showNetworkMenuButtonExpression": true, "showNetworkMenuButtonScreenshot": true,"showNetworkMenuButtonExportGraphml": true,"showNetworkMenuButtonAdjacentDrugs": true,"showNetworkMenuButtonCenter": true,"showConnectGenes": false,"networkMenuButtonAdjacentDrugsLabel": "Drugs","showNetworkMenuButtonAdjacentDisordersProteins": true,"networkMenuButtonAdjacentDisordersProteinsLabel": "Disorders (protein)","showNetworkMenuButtonAdjacentDisordersDrugs": true,"networkMenuButtonAdjacentDisordersDrugsLabel": "Disorders (drug)","showNetworkMenuButtonAnimation": true,"networkMenuButtonAnimationLabel": "Animation", "autofillEdges": true, "physicsOn": false,"useNedrexLicenced": true,"selfReferences": false, "interactionDrugProtein": "NeDRex", "indicationDrugDisorder": "NeDRex","nodeShadow": true,"edgeShadow": true, "algorithms": {"drug": ["trustrank", "closeness", "degree", "proximity"], "drug-target": ["trustrank", "multisteiner", "keypathwayminer", "degree", "closeness", "betweenness"]}, "associatedProteinDisorder": "NeDRex", "expandNetworkMenu": true}'
network='{"nodes": [{"id":"PSEN1","group":"Protein","label":"PSEN1"},{"id":"PSEN2","group":"Protein","label":"PSEN2"},{"id":"APP","group":"Protein","label":"APP"},{"id":"APOE","group":"Protein","label":"APOE"},{"id":"RNF32","group":"Protein","label":"RNF32"},{"id":"STX5","group":"Protein","label":"STX5"},{"id":"TRAF3IP1","group":"Protein","label":"TRAF3IP1"},{"id":"PHB1","group":"Protein","label":"PHB1"},{"id":"MAPT","group":"Protein","label":"MAPT"},{"id":"ESR1","group":"Protein","label":"ESR1"},{"id":"IRF3","group":"Protein","label":"IRF3"},{"id":"DYNC1H1","group":"Protein","label":"DYNC1H1"},{"id":"CUL3","group":"Protein","label":"CUL3"},{"id":"HMGB1","group":"Protein","label":"HMGB1"},{"id":"DNAJC7","group":"Protein","label":"DNAJC7"},{"id":"NEFM","group":"Protein","label":"NEFM"},{"id":"DISC1","group":"Protein","label":"DISC1"},{"id":"PPP5C","group":"Protein","label":"PPP5C"},{"id":"CTNNB1","group":"Protein","label":"CTNNB1"},{"id":"KRAS","group":"Protein","label":"KRAS"}]}' network='{"nodes": [{"id":"PSEN1","group":"Protein","label":"PSEN1"},{"id":"PSEN2","group":"Protein","label":"PSEN2"},{"id":"APP","group":"Protein","label":"APP"},{"id":"APOE","group":"Protein","label":"APOE"},{"id":"RNF32","group":"Protein","label":"RNF32"},{"id":"STX5","group":"Protein","label":"STX5"},{"id":"TRAF3IP1","group":"Protein","label":"TRAF3IP1"},{"id":"PHB1","group":"Protein","label":"PHB1"},{"id":"MAPT","group":"Protein","label":"MAPT"},{"id":"ESR1","group":"Protein","label":"ESR1"},{"id":"IRF3","group":"Protein","label":"IRF3"},{"id":"DYNC1H1","group":"Protein","label":"DYNC1H1"},{"id":"CUL3","group":"Protein","label":"CUL3"},{"id":"HMGB1","group":"Protein","label":"HMGB1"},{"id":"DNAJC7","group":"Protein","label":"DNAJC7"},{"id":"NEFM","group":"Protein","label":"NEFM"},{"id":"DISC1","group":"Protein","label":"DISC1"},{"id":"PPP5C","group":"Protein","label":"PPP5C"},{"id":"CTNNB1","group":"Protein","label":"CTNNB1"},{"id":"KRAS","group":"Protein","label":"KRAS"}]}'
></drugst-one> ></drugst-one>
......
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